Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C24H19ClN4O4.ClH |
| Molecular Weight | 499.346 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.COC(=O)NC1=NC2=C(N1)C=CC(=C2)C3(O)N(C(=O)C4=CC=CC=C34)C5=C(C)C=CC(Cl)=C5
InChI
InChIKey=ACFCZHQPGRDESJ-UHFFFAOYSA-N
InChI=1S/C24H19ClN4O4.ClH/c1-13-7-9-15(25)12-20(13)29-21(30)16-5-3-4-6-17(16)24(29,32)14-8-10-18-19(11-14)27-22(26-18)28-23(31)33-2;/h3-12,32H,1-2H3,(H2,26,27,28,31);1H
| Molecular Formula | C24H19ClN4O4 |
| Molecular Weight | 462.885 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
BMS-908662 (previously known as XL281) is a small molecule Raf kinase inhibitor that lies immediately downstream of RAS and are key components of the RAS/RAF/MEK/ERK kinase-signaling pathway. Bristol-Myers Squibb has received an exclusive worldwide license to develop and commercialize antineoplastic agent XL281. BMS-908662 participated in phase I development for the treatment of patients with melanoma and in combination with cetuximab for patients with colorectal cancer. However, further, development has been discontinued.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Phase I study of XL281 (BMS-908662), a potent oral RAF kinase inhibitor, in patients with advanced solid tumors. | 2015-04 |
|
| Clinico-morphological features of BRAF inhibition-induced proliferative skin lesions in cancer patients. | 2015-01-01 |
|
| Paradoxical activation of T cells via augmented ERK signaling mediated by a RAF inhibitor. | 2014-01 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:16:56 GMT 2025
by
admin
on
Mon Mar 31 18:16:56 GMT 2025
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| Record UNII |
VRO412Z1ZG
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| Record Status |
Validated (UNII)
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| Record Version |
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Preferred Name | English |
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VRO412Z1ZG
Created by
admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
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