Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H9FN2.BrH |
| Molecular Weight | 317.156 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Br.CC1=NC(=CC=C1)C#CC2=CC(=CC(F)=C2)C#N
InChI
InChIKey=OEELBDJXBNRCRD-UHFFFAOYSA-N
InChI=1S/C15H9FN2.BrH/c1-11-3-2-4-15(18-11)6-5-12-7-13(10-17)9-14(16)8-12;/h2-4,7-9H,1H3;1H
| Molecular Formula | BrH |
| Molecular Weight | 80.912 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C15H9FN2 |
| Molecular Weight | 236.2438 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
MFZ 10-7 is a high affinity negative allosteric modulator at the mGlu5 receptor (Ki = 0.67 nM). MFZ 10-7 demonstrates anxyolitic properties in mouse models. Intraperitoneal administration of MFZ 10-7 inhibited intravenous cocaine self-administration, cocaine-induced reinstatement of drug-seeking behavior and cocaine-associated cue-induced cocaine-seeking behavior in rats.
CNS Activity
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Potent mGluR5 antagonists: pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series. | 2011 Jun 1 |
|
| Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. | 2012 Jul 12 |
|
| A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats. | 2014 Mar |
Patents
Sample Use Guides
For anxyolitic tests MFZ 10-7 was delivered via ip injection 15 min prior to testing. Anxyolitic effects were observed at dose 0.3 mg/kg.
Route of Administration:
Intraperitoneal
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 19:19:53 GMT 2023
by
admin
on
Sat Dec 16 19:19:53 GMT 2023
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| Record UNII |
VQ47T8DE6U
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| Record Status |
Validated (UNII)
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| Record Version |
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1380072-52-5
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166177251
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admin on Sat Dec 16 19:19:53 GMT 2023 , Edited by admin on Sat Dec 16 19:19:53 GMT 2023
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| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
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