| Stereochemistry | ABSOLUTE |
| Molecular Formula | C27H30O14 |
| Molecular Weight | 578.5187 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 10 / 10 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@@H]1O[C@@H](OC2=CC(O)=C3C(=O)C(O[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)=C(OC3=C2)C5=CC=C(O)C=C5)[C@H](O)[C@H](O)[C@H]1O
InChI
InChIKey=PUPKKEQDLNREIM-QNSQPKOQSA-N
InChI=1S/C27H30O14/c1-9-17(30)20(33)22(35)26(37-9)39-13-7-14(29)16-15(8-13)40-24(11-3-5-12(28)6-4-11)25(19(16)32)41-27-23(36)21(34)18(31)10(2)38-27/h3-10,17-18,20-23,26-31,33-36H,1-2H3/t9-,10-,17-,18-,20+,21+,22+,23+,26-,27-/m0/s1
| Molecular Formula | C27H30O14 |
| Molecular Weight | 578.5187 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 10 / 10 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Lespedin (Kaempferitrin) is extracted in significantly high quantities from the leaves of Cinnamomum osmophloeum (C.O) and Bauhinia forficata, and are used as an antidiabetic herbal remedy in China and Brazil. Commercial product using dry Cinnamomum osmophloeum leaves has been sold locally in Taiwan. Oral administration of kaempferitrin reduced blood sugar in diabetic rats. Lespedin possessed significant antiosteoporotic activity. Combined with its limited estrogen-like side effect, Lespedin can be regarded as an idealistic antiosteoporotic candidate for human osteoporosis diseases. Kaempferitrin was found to have an acute lowering effect on blood glucose in diabetic rats and to stimulate the glucose uptake percentile, as efficiently as insulin in muscle from normal rats.
CNS Activity
Originator
Approval Year
PubMed
Patents
Sample Use Guides
Lespedin (Kaempferitrin) and ETX were administered via intracerebroventricular (i.c.v, 4th ventricle, 1ug/μL) and tested in the presence of PTZ in rats.
Route of Administration:
Other
