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Details

Stereochemistry ABSOLUTE
Molecular Formula C29H29F3N2O2.ClH
Molecular Weight 531.009
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DAGROCORAT HYDROCHLORIDE

SMILES

Cl.CC1=NC=CC=C1NC(=O)C2=CC=C3C(CC[C@@H]4C[C@](O)(CC[C@@]34CC5=CC=CC=C5)C(F)(F)F)=C2

InChI

InChIKey=IHLZSINDEDTWTB-KKVPRZDISA-N
InChI=1S/C29H29F3N2O2.ClH/c1-19-25(8-5-15-33-19)34-26(35)22-10-12-24-21(16-22)9-11-23-18-28(36,29(30,31)32)14-13-27(23,24)17-20-6-3-2-4-7-20;/h2-8,10,12,15-16,23,36H,9,11,13-14,17-18H2,1H3,(H,34,35);1H/t23-,27+,28-;/m1./s1

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C29H29F3N2O2
Molecular Weight 494.548
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 3 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Pfizer developed fosdagrocorat (PF-04171327), a dissociated agonist of the glucocorticoid receptor for the treatment of rheumatoid arthritis. The drug successfully completed the phase II clinical trial; however, further study of the drug was discontinued.

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
Fosdagrocorat (PF-04171327) versus prednisone or placebo in rheumatoid arthritis: a randomised, double-blind, multicentre, phase IIb study.
2019
Population Pharmacokinetics of Fosdagrocorat (PF-04171327), a Dissociated Glucocorticoid Receptor Agonist, in Patients With Rheumatoid Arthritis.
2018-01
Improved disease activity with fosdagrocorat (PF-04171327), a partial agonist of the glucocorticoid receptor, in patients with rheumatoid arthritis: a Phase 2 randomized study.
2017-08
Pharmacokinetics and food-effect of fosdagrocorat (PF-04171327), a dissociated agonist of the glucocorticoid receptor, in healthy adult Caucasian and Japanese subjects
.
2016-12
Patents

Patents

20080188443
3
20080312294
3
20090281148
3
20100286214
3
Substance Class Chemical
Created
by admin
on Mon Mar 31 22:21:18 GMT 2025
Edited
by admin
on Mon Mar 31 22:21:18 GMT 2025
Record UNII
VL45KV749O
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DAGROCORAT HYDROCHLORIDE
Common Name English
PF-0251802 HYDROCHLORIDE
Preferred Name English
2-PHENANTHRENECARBOXAMIDE, 4B,5,6,7,8,8A,9,10-OCTAHYDRO-7-HYDROXY-N-(2-METHYL-3-PYRIDINYL)-4B-(PHENYLMETHYL)-7-(TRIFLUOROMETHYL)-, HYDROCHLORIDE (1:1), (4BS,7R,8AR)-
Systematic Name English
Code System Code Type Description
DRUG BANK
DBSALT002795
Created by admin on Mon Mar 31 22:21:18 GMT 2025 , Edited by admin on Mon Mar 31 22:21:18 GMT 2025
PRIMARY
PUBCHEM
25157943
Created by admin on Mon Mar 31 22:21:18 GMT 2025 , Edited by admin on Mon Mar 31 22:21:18 GMT 2025
PRIMARY
FDA UNII
VL45KV749O
Created by admin on Mon Mar 31 22:21:18 GMT 2025 , Edited by admin on Mon Mar 31 22:21:18 GMT 2025
PRIMARY
CAS
1044535-61-6
Created by admin on Mon Mar 31 22:21:18 GMT 2025 , Edited by admin on Mon Mar 31 22:21:18 GMT 2025
PRIMARY
Related Record Type Details
Structure of DAGROCORAT
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of DAGROCORAT
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