Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C29H29F3N2O2.ClH |
| Molecular Weight | 531.009 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.[H][C@]12CCC3=CC(=CC=C3[C@]1(CC4=CC=CC=C4)CC[C@@](O)(C2)C(F)(F)F)C(=O)NC5=CC=CN=C5C
InChI
InChIKey=IHLZSINDEDTWTB-KKVPRZDISA-N
InChI=1S/C29H29F3N2O2.ClH/c1-19-25(8-5-15-33-19)34-26(35)22-10-12-24-21(16-22)9-11-23-18-28(36,29(30,31)32)14-13-27(23,24)17-20-6-3-2-4-7-20;/h2-8,10,12,15-16,23,36H,9,11,13-14,17-18H2,1H3,(H,34,35);1H/t23-,27+,28-;/m1./s1
| Molecular Formula | C29H29F3N2O2 |
| Molecular Weight | 494.548 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pharmacokinetics and food-effect of fosdagrocorat (PF-04171327), a dissociated agonist of the glucocorticoid receptor, in healthy adult Caucasian and Japanese subjects . | 2016 Dec |
|
| Improved disease activity with fosdagrocorat (PF-04171327), a partial agonist of the glucocorticoid receptor, in patients with rheumatoid arthritis: a Phase 2 randomized study. | 2017 Aug |
|
| Population Pharmacokinetics of Fosdagrocorat (PF-04171327), a Dissociated Glucocorticoid Receptor Agonist, in Patients With Rheumatoid Arthritis. | 2018 Jan |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:52:36 UTC 2023
by
admin
on
Sat Dec 16 08:52:36 UTC 2023
|
| Record UNII |
VL45KV749O
|
| Record Status |
Validated (UNII)
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| Record Version |
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DBSALT002795
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25157943
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VL45KV749O
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1044535-61-6
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admin on Sat Dec 16 08:52:36 UTC 2023 , Edited by admin on Sat Dec 16 08:52:36 UTC 2023
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ACTIVE MOIETY |