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Details

Stereochemistry ACHIRAL
Molecular Formula C23H21ClN6O3.CH4O3S
Molecular Weight 561.01
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of LOPRAZOLAM MESILATE

SMILES

CS(O)(=O)=O.CN1CCN(CC1)\C=C2/N=C3CN=C(C4=CC=CC=C4Cl)C5=CC(=CC=C5N3C2=O)[N+]([O-])=O

InChI

InChIKey=DDSDPQHQLNAGLJ-YEBWQKSTSA-N
InChI=1S/C23H21ClN6O3.CH4O3S/c1-27-8-10-28(11-9-27)14-19-23(31)29-20-7-6-15(30(32)33)12-17(20)22(25-13-21(29)26-19)16-4-2-3-5-18(16)24;1-5(2,3)4/h2-7,12,14H,8-11,13H2,1H3;1H3,(H,2,3,4)/b19-14-;

HIDE SMILES / InChI

Molecular Formula CH4O3S
Molecular Weight 96.106
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C23H21ClN6O3
Molecular Weight 464.904
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description
Sources: www.mhra.gov.uk/home/groups/par/documents/websiteresources/con418469.pdf
Curator's Comment: description was created based on several sources, including, http://home.intekom.com/pharm/hmr/dormnoct.html

Loprazolam is a hypnotic drug which stimulates GABA-A receptors. Due to its hypnotic activity the drug is used to treat short-term sleep disordes.

CNS Activity

Curator's Comment: The drug is hypnotic.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: CHEMBL2109243
Sources: www.mhra.gov.uk/home/groups/par/documents/websiteresources/con418469.pdf
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
DORMONOCT

Approved Use

Short-term treatment of insomnia.Sleep disturbances in the geriatric patient. Pre-operative sleep disturbances.
PubMed

PubMed

TitleDatePubMed
A comparison of the hypnotic activity of loprazolam, temazepam and placebo in general practice.
1984
Patents

Patents

Sample Use Guides

The usual adult dose is 1 - 2 mg at bedtime.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:37:41 GMT 2023
Edited
by admin
on Fri Dec 15 18:37:41 GMT 2023
Record UNII
VKF8383J65
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LOPRAZOLAM MESILATE
MART.   WHO-DD  
Common Name English
Loprazolam mesilate [WHO-DD]
Common Name English
RU-31158
Code English
SOMNOVIT
Brand Name English
1H-IMIDAZO(1,2-A)(1,4)BENZODIAZEPIN-1-ONE, 6-(2-CHLOROPHENYL)-2,4-DIHYDRO-2-((4-METHYL-1-PIPERAZINYL)METHYLENE)-8-NITRO-, (2Z)-, METHANESULFONATE (1:1)
Systematic Name English
SONIN
Brand Name English
LOPRAZOLAM METHANESULFONATE
MI  
Common Name English
LOPRAZOLAM MESILATE [MART.]
Common Name English
LOPRAZOLAM METHANESULFONATE [MI]
Common Name English
HR-158
Code English
LOPRAZOLAM MESYLATE
Common Name English
DORMONOCT
Brand Name English
HAVLANE
Brand Name English
Code System Code Type Description
CAS
70111-54-5
Created by admin on Fri Dec 15 18:37:41 GMT 2023 , Edited by admin on Fri Dec 15 18:37:41 GMT 2023
PRIMARY
EVMPD
SUB02971MIG
Created by admin on Fri Dec 15 18:37:41 GMT 2023 , Edited by admin on Fri Dec 15 18:37:41 GMT 2023
PRIMARY
WIKIPEDIA
Loprazolam mesylate
Created by admin on Fri Dec 15 18:37:41 GMT 2023 , Edited by admin on Fri Dec 15 18:37:41 GMT 2023
PRIMARY
PUBCHEM
6917853
Created by admin on Fri Dec 15 18:37:41 GMT 2023 , Edited by admin on Fri Dec 15 18:37:41 GMT 2023
PRIMARY
CAS
61197-93-1
Created by admin on Fri Dec 15 18:37:41 GMT 2023 , Edited by admin on Fri Dec 15 18:37:41 GMT 2023
NON-SPECIFIC STOICHIOMETRY
MERCK INDEX
m6901
Created by admin on Fri Dec 15 18:37:41 GMT 2023 , Edited by admin on Fri Dec 15 18:37:41 GMT 2023
PRIMARY Merck Index
FDA UNII
VKF8383J65
Created by admin on Fri Dec 15 18:37:41 GMT 2023 , Edited by admin on Fri Dec 15 18:37:41 GMT 2023
PRIMARY
RXCUI
235846
Created by admin on Fri Dec 15 18:37:41 GMT 2023 , Edited by admin on Fri Dec 15 18:37:41 GMT 2023
PRIMARY RxNorm
SMS_ID
100000085062
Created by admin on Fri Dec 15 18:37:41 GMT 2023 , Edited by admin on Fri Dec 15 18:37:41 GMT 2023
PRIMARY
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