LOPRAZOLAM MESILATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H21ClN6O3.CH4O3S
Molecular Weight	561.01
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CS(O)(=O)=O.CN1CCN(CC1)\C=C2/N=C3CN=C(C4=CC=CC=C4Cl)C5=CC(=CC=C5N3C2=O)[N+]([O-])=O

InChI

InChIKey=DDSDPQHQLNAGLJ-YEBWQKSTSA-N

InChI=1S/C23H21ClN6O3.CH4O3S/c1-27-8-10-28(11-9-27)14-19-23(31)29-20-7-6-15(30(32)33)12-17(20)22(25-13-21(29)26-19)16-4-2-3-5-18(16)24;1-5(2,3)4/h2-7,12,14H,8-11,13H2,1H3;1H3,(H,2,3,4)/b19-14-;

HIDE SMILES / InChI

Molecular Formula	CH4O3S
Molecular Weight	96.106
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C23H21ClN6O3
Molecular Weight	464.904
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: www.mhra.gov.uk/home/groups/par/documents/websiteresources/con418469.pdf
Curator's Comment: description was created based on several sources, including, http://home.intekom.com/pharm/hmr/dormnoct.html

Loprazolam is a hypnotic drug which stimulates GABA-A receptors. Due to its hypnotic activity the drug is used to treat short-term sleep disordes.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
GABA-A receptor; benzodiazepine site 38 Target ID: CHEMBL2109243 Sources: www.mhra.gov.uk/home/groups/par/documents/websiteresources/con418469.pdf	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Short term slep problems 3 Sources: http://home.intekom.com/pharm/hmr/dormnoct.html	Primary		Approved 8429	DORMONOCT Approved Use Short-term treatment of insomnia.Sleep disturbances in the geriatric patient. Pre-operative sleep disturbances.

PubMed

Title	Date	PubMed
A comparison of the hypnotic activity of loprazolam, temazepam and placebo in general practice.	1984	6141114

Patents

Sample Use Guides

In Vivo Use Guide

The usual adult dose is 1 - 2 mg at bedtime.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:37:41 UTC 2023` Edited by `admin` on `Fri Dec 15 18:37:41 UTC 2023`
Record UNII	VKF8383J65
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LOPRAZOLAM MESILATE

Common Name

English

Loprazolam mesilate [WHO-DD]

Common Name

English

RU-31158

Code

English

SOMNOVIT

Brand Name

English

1H-IMIDAZO(1,2-A)(1,4)BENZODIAZEPIN-1-ONE, 6-(2-CHLOROPHENYL)-2,4-DIHYDRO-2-((4-METHYL-1-PIPERAZINYL)METHYLENE)-8-NITRO-, (2Z)-, METHANESULFONATE (1:1)

Systematic Name

English

SONIN

Brand Name

English

LOPRAZOLAM METHANESULFONATE

Common Name

English

LOPRAZOLAM MESILATE [MART.]

Common Name

English

LOPRAZOLAM METHANESULFONATE [MI]

Common Name

English

HR-158

Code

English

LOPRAZOLAM MESYLATE

Common Name

English

DORMONOCT

Brand Name

English

HAVLANE

Brand Name

English

Code System Code Type Description

CAS

70111-54-5