LONIGUTAMAB UGODOTIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 11:43:47 GMT 2025` Edited by `admin` on `Wed Apr 02 11:43:47 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Type	COMPLETE
Record UNII	VJ9X8A8CJ5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IMMUNOGLOBULIN G1 (DE-C-TERMINAL-LYSINE), ANTI-(HUMAN INSULIN-LIKE GROWTH FACTOR I RECEPTOR) (HUMAN-MUS MUSCULUS MONOCLONAL HZ-208F2-4 .GAMMA.1-CHAIN), COMPLEX WITH HUMAN-MUS MUSCULUS MONOCLONAL HZ-208F2-4 .KAPPA.-CHAIN, DIMER, TETRAKIS(THIOETHER) WITH N

Preferred Name

English

LONIGUTAMAB UGODOTIN

Official Name

English

IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS IGF1R (INSULIN LIKE GROWTH FACTOR 1 RECEPTOR, IGF1-R, IGF-1R, CD221)), HUMANIZED MONOCLONAL ANTIBODY CONJUGATED TO A DOLASTATIN DERIVATIVE (UGODOTIN GROUPS)

Common Name

English

lonigutamab ugodotin [INN]

Common Name

English

Code System Code Type Description

INN

11640

Created by admin on Wed Apr 02 11:43:47 GMT 2025 , Edited by admin on Wed Apr 02 11:43:47 GMT 2025

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INN

FDA UNII

VJ9X8A8CJ5

Created by admin on Wed Apr 02 11:43:47 GMT 2025 , Edited by admin on Wed Apr 02 11:43:47 GMT 2025

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SMS_ID

300000038042

Created by admin on Wed Apr 02 11:43:47 GMT 2025 , Edited by admin on Wed Apr 02 11:43:47 GMT 2025

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NCI_THESAURUS

C179101

Created by admin on Wed Apr 02 11:43:47 GMT 2025 , Edited by admin on Wed Apr 02 11:43:47 GMT 2025

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CAS

2363754-30-5

Created by admin on Wed Apr 02 11:43:47 GMT 2025 , Edited by admin on Wed Apr 02 11:43:47 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_147	2_203
2_264	2_324
1_147	1_203
2_370	2_428
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					56GN9PT35D

PARENT -> CONJUGATE

Amount:


					1Z1AI9IW5L

MONOMETHYL AURISTATIN F

CONJUGATE COMPONENT->CONJUGATE

Amount:


					DK7PL4F3TT

INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR

TARGET->LIGAND

Amount:

Related Record Type Details


					VJ9X8A8CJ5

LONIGUTAMAB UGODOTIN

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_223] [2_223] [3_214] [4_214]	SITE_SPECIFIC			CYSTEINYL UGODOTIN	LV69A75EA5

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL