GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 18:13:09 GMT 2025` Edited by `admin` on `Tue Apr 01 18:13:09 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	VH92ICR8HX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GLUN2A

Preferred Name

English

GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A

Common Name

English

HNR2A

Common Name

English

N-METHYL D-ASPARTATE RECEPTOR SUBTYPE 2A

Common Name

English

NMDAR2A

Common Name

English

GLUTAMATE (NMDA) RECEPTOR SUBUNIT EPSILON-1

Common Name

English

Code System Code Type Description

FDA UNII

VH92ICR8HX

Created by admin on Tue Apr 01 18:13:09 GMT 2025 , Edited by admin on Tue Apr 01 18:13:09 GMT 2025

PRIMARY

From	To
1_65	1_298

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_53
N	1_318
N	1_358
N	1_421
N	1_422
N	1_519

Related Record Type Details


					LE8K7M4APN

PEAQX

INHIBITOR -> TARGET

Comments:

the Ki of PEAQX revealed it only shows a 5 fold difference in affinity for GluN1/GluN2A vs. GluN1/GluN2B receptors. It is also a potent anticonvulsant in animal tests.

Interaction Type:

COMPETITIVE ANTAGONIST

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_860] [1_868] [1_907] [1_1003] [1_1037] [1_1040] [1_1176]				DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL