Rezpegaldesleukin

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 02:32:57 GMT 2025` Edited by `admin` on `Wed Apr 02 02:32:57 GMT 2025`
Protein Type	CYTOKINE
Protein Sub Type	IMMUNOMODULATOR
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	VGR86P26ER
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

INTERLEUKIN 2 (DE-1-ALANINE,125-SERINE) (RECOMBINANT HUMAN), N6-(4-(2-((((2-HYDROXYETHYL)AMINO)CARBONYL)OXY)-1-(((((2-HYDROXYETHYL)AMINO)CARBONYL)OXY) METHYL)ETHOXY)-1-OXOBUTYL)-L-LYSINE DIETHER WITH .ALPHA.-HYDRO-.OMEGA.-METHOXYPOLY(OXY-1,2-ETHANEDIYL)

Preferred Name

English

Rezpegaldesleukin

Official Name

English

LY-3471851

Code

English

Rezpegaldesleukin [WHO-DD]

Common Name

English

LY3471851

Code

English

rezpegaldesleukin [INN]

Common Name

English

IL-2 PEG CONJUGATE (NKTR-358)

Common Name

English

NKTR-358

Code

English

REZPEGALDESLEUKIN [USAN]

Common Name

English

Code System Code Type Description

INN

12380

Created by admin on Wed Apr 02 02:32:57 GMT 2025 , Edited by admin on Wed Apr 02 02:32:57 GMT 2025

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SMS_ID

300000019014

Created by admin on Wed Apr 02 02:32:57 GMT 2025 , Edited by admin on Wed Apr 02 02:32:57 GMT 2025

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FDA UNII

VGR86P26ER

Created by admin on Wed Apr 02 02:32:57 GMT 2025 , Edited by admin on Wed Apr 02 02:32:57 GMT 2025

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USAN

JK-147

Created by admin on Wed Apr 02 02:32:57 GMT 2025 , Edited by admin on Wed Apr 02 02:32:57 GMT 2025

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CAS

2641686-76-0

Created by admin on Wed Apr 02 02:32:57 GMT 2025 , Edited by admin on Wed Apr 02 02:32:57 GMT 2025

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NCI_THESAURUS

C188643

Created by admin on Wed Apr 02 02:32:57 GMT 2025 , Edited by admin on Wed Apr 02 02:32:57 GMT 2025

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From	To
1_57	1_104

Related Record Type Details


					EQ4MX58AP3

INTERLEUKIN-2 RECEPTOR

TARGET -> AGONIST

Amount:

Related Record Type Details


					VGR86P26ER

Rezpegaldesleukin

ACTIVE MOIETY

Comments:

It targets the interleukin (IL-2) receptor complex in the body in order to stimulate proliferation of inhibitory immune cells known as regulatory T cells. By activating these cells

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION		RESIDUE_SPECIFIC		Amount:	MPEG20000-CARBAMOYL-4-HYDROXYBUTANAMIDE-LYSINE	4LT8284ZFI

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL