U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Wed Apr 02 19:35:25 GMT 2025
Edited
by admin
on Wed Apr 02 19:35:25 GMT 2025
Source Materials Class ORGANISM
Source Materials Type RECOMBINANT VIRUS
Source Materials State LIVE NON-REPLICATING GENETICALLY MODIFIED
Organism Family Parvoviridae
Organism Genus Dependovirus
Organism Species adeno-associated virus
Infraspecific Type RECOMBINANT VECTOR
Infraspecific Name 4D-150 (4D-R100.CAG-miR-(VEGFC)-coAFLB)
Part whole
Record UNII
VFF5C4QV72
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Adeno-associated virus vector 4D-150
Preferred Name English
Zunibergene Rocparvovec
INN  
Official Name English
DNA (recombinant replication-defective adeno-associated virus vector 4D-150 cytomegalovirus immediate-early enhancer element plus chicken ?-actin exon 1 plus intron 1 plus vascular endothelial growth factor C-specific microRNA gene plus chicken ?-actin i
Common Name English
zunibergene rocparvovec [INN]
Common Name English
recombinant non-replicating adeno-associated virus (AAV) vector with a retina-specific capsid variant, encoding a microRNA (miRNA) targeting expression of vascular endothelial growth factor C (VEGF-C) and a codon-optimised fusion protein that consists of
Common Name English
Code System Code Type Description
CAS
2856381-73-0
Created by admin on Wed Apr 02 19:35:25 GMT 2025 , Edited by admin on Wed Apr 02 19:35:25 GMT 2025
PRIMARY
INN
13246
Created by admin on Wed Apr 02 19:35:25 GMT 2025 , Edited by admin on Wed Apr 02 19:35:25 GMT 2025
PRIMARY
SMS_ID
300000051583
Created by admin on Wed Apr 02 19:35:25 GMT 2025 , Edited by admin on Wed Apr 02 19:35:25 GMT 2025
PRIMARY
FDA UNII
VFF5C4QV72
Created by admin on Wed Apr 02 19:35:25 GMT 2025 , Edited by admin on Wed Apr 02 19:35:25 GMT 2025
PRIMARY
NCI_THESAURUS
C211814
Created by admin on Wed Apr 02 19:35:25 GMT 2025 , Edited by admin on Wed Apr 02 19:35:25 GMT 2025
PRIMARY
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
INSERTED GENE EXPRESSION VECTOR Zunibergene rocparvovec transgene insert XN2UJS98KS