MECBOTAMAB VEDOTIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 01:44:05 GMT 2025` Edited by `admin` on `Wed Apr 02 01:44:05 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	VF40YVX65F
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BA-3011

Preferred Name

English

MECBOTAMAB VEDOTIN

Official Name

English

IMMUNOGLOBULIN G1 (DE-450-LYSINE), ANTI-(HUMAN TYROSINE KINASE RECEPTOR AXL) (HUMAN-MUS MUSCULUS MONOCLONAL BA301 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL BA301 .KAPPA.-CHAIN, DIMER, THIOETHER WITH N-(((4-((N-(6-(3-MERCAPTO-2,5-DIOXO

Common Name

English

MECBOTAMAB VEDOTIN [USAN]

Common Name

English

Mecbotamab vedotin [WHO-DD]

Common Name

English

mecbotamab vedotin [INN]

Common Name

English

BA3011

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

659718

Created by admin on Wed Apr 02 01:44:05 GMT 2025 , Edited by admin on Wed Apr 02 01:44:05 GMT 2025

FDA ORPHAN DRUG

802920

Created by admin on Wed Apr 02 01:44:05 GMT 2025 , Edited by admin on Wed Apr 02 01:44:05 GMT 2025

Code System Code Type Description

INN

11946

Created by admin on Wed Apr 02 01:44:05 GMT 2025 , Edited by admin on Wed Apr 02 01:44:05 GMT 2025

PRIMARY

SMS_ID

300000039973

Created by admin on Wed Apr 02 01:44:05 GMT 2025 , Edited by admin on Wed Apr 02 01:44:05 GMT 2025

PRIMARY

CAS

2460400-64-8

Created by admin on Wed Apr 02 01:44:05 GMT 2025 , Edited by admin on Wed Apr 02 01:44:05 GMT 2025

PRIMARY

NCI_THESAURUS

C156141

Created by admin on Wed Apr 02 01:44:05 GMT 2025 , Edited by admin on Wed Apr 02 01:44:05 GMT 2025

PRIMARY

USAN

JK-82

Created by admin on Wed Apr 02 01:44:05 GMT 2025 , Edited by admin on Wed Apr 02 01:44:05 GMT 2025

PRIMARY

FDA UNII

VF40YVX65F

Created by admin on Wed Apr 02 01:44:05 GMT 2025 , Edited by admin on Wed Apr 02 01:44:05 GMT 2025

PRIMARY

From	To
1_22	1_96
1_147	1_203
1_223	3_214
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428
2_22	2_96
2_147	2_203
2_223	4_214
2_264	2_324
2_370	2_428
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					5Q5W4H8T1J

CONJUGATE COMPONENT->CONJUGATE

Amount:


					8EJE45ZR0I

TYROSINE-PROTEIN KINASE RECEPTOR UFO

TARGET->LIGAND

Amount:


					6603L01WUR

Cysteinyl vedotin

CONJUGATE COMPONENT->CONJUGATE

Amount:

Related Record Type Details


					V7I58RC5EJ

MONOMETHYL AURISTATIN E

METABOLITE ACTIVE -> PARENT

Comments:

ASSUMED FROM BRENTUXIMAB VEDOTIN RECORD

Amount:

Related Record Type Details


					VF40YVX65F

MECBOTAMAB VEDOTIN

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION		RESIDUE_SPECIFIC	C	Amount:	Cysteinyl vedotin	6603L01WUR

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL