Pegpleranib

Investigational

Approval Year

Substance Class	Nucleic Acid
Sequence Type	COMPLETE
Record UNII	VER541H6NK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

pegpleranib [INN]

Preferred Name

English

Pegpleranib

Official Name

English

Pegpleranib [WHO-DD]

Common Name

English

Poly(oxy-1,2-ethanediyl), ?-hydro-?-methoxy-, 5?-ester with DNA d(C-A-G-G-C-(2?-deoxy-2?-fluoro)rU-A-(2?-deoxy-2?-fluoro)rC-rGm(oxyphosphinicooxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxy-1,2-ethanediyloxyp

Common Name

English

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Code System

Code

Type

Description

NCI_THESAURUS

C170303

PRIMARY

FDA UNII

VER541H6NK

PRIMARY

INN

10044

PRIMARY

CAS

1618657-13-8

PRIMARY

EVMPD

SUB181666

PRIMARY

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Subunit 0

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Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_6;1_8;1_19-1_20;1_26-1_28	7 / 30
Deoxyribose (DNA)	1_1-1_5;1_7;1_10-1_13;1_15;1_17-1_18;1_22-1_25;1_30	18 / 30
2'-O-Methyl-Ribose	1_9;1_14;1_16;1_21;1_29	5 / 30

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Linkage	Site Range	Site Count
	1_10;1_22	2 / 29
	1_2-1_9;1_11-1_21;1_23-1_30	27 / 29

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Related Record

Type

Details


					VER541H6NK

Pegpleranib

ACTIVE MOIETY

Amount:

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Structural Modifications

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Modification Type	Location Site	Location Type	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_21]	SITE_SPECIFIC	(5'-PEG6-3')-2'-O-METHYLADENOSINE	CH9LB7891N
NUCLEOTIDE SUBSTITUTION	[1_9]	SITE_SPECIFIC	(5'-PEG6-3')-2'-O-METHYLGUANOSINE	Y11F2IW8DG
PEGYLATION	[1_1]	5'-TERMINUS	PEGPLERANIB 5'- MODIFICATION	CN522YPB8E
NUCLEOTIDE SUBSTITUTION	[1_30]	SITE_SPECIFIC	THYMIDINE 3'-MONOPHOSPHATE	Q84LAH3NDH

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(sizeexclusionchromatography)	CHEMICAL	NUMBER 50 kDa (average)

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