IODOPYRACET I-131

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H5I2NO3.C4H11NO2
Molecular Weight	518.0674
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCCNCCO.OC(=O)CN1C=C([131I])C(=O)C([131I])=C1

InChI

InChIKey=RERHJVNYJKZHLJ-QHFVJCKDSA-N

InChI=1S/C7H5I2NO3.C4H11NO2/c8-4-1-10(3-6(11)12)2-5(9)7(4)13;6-3-1-5-2-4-7/h1-2H,3H2,(H,11,12);5-7H,1-4H2/i8+4,9+4;

HIDE SMILES / InChI

Molecular Formula	C7H5I2NO3
Molecular Weight	412.9317
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C4H11NO2
Molecular Weight	105.1356
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13648987 | https://www.ncbi.nlm.nih.gov/pubmed/26819427 | https://www.ncbi.nlm.nih.gov/pubmed/2374087 |

Iodopyracet (Diodone) is a radiocontrast agent used in urography before 1950. Renal clearance of iodopyracet is characterized by supply-limited elimination at low plasma concentrations and capacity-limited elimination at high plasma levels. Iodopyracet to be an effective agent for the estimation of renal plasma flow and tubular function has been used extensively in physiological studies. In 1945 was found, that p-aminohippuric acid was in some ways superior to diodone for these estimations in man because the urine and plasma blanks are small and because diodone penetrates human red blood cells whereas p-aminohippuric acid does not.

Approval Year

PubMed

Title	Date	PubMed
Physiologically based pharmacokinetic model for the renal clearance of iodopyracet and the interaction with probenecid in the dog.	1989 Mar-Apr	2706315

Sample Use Guides

In Vivo Use Guide

3.0 g, administered i.v.

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:30:57 GMT 2023` Edited by `admin` on `Sat Dec 16 05:30:57 GMT 2023`
Record UNII	VEN7B6V3XF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IODOPYRACET I-131

Common Name

English

1(4H)-PYRIDINEACETIC ACID, 3,5-DI(IODO-131I)-4-OXO-, COMPD. WITH 2,2'-IMINOBIS(ETHANOL)(1:1)

Common Name

English

1(4H)-PYRIDINEACETIC ACID, 3,5-DI(IODO-131I)-4-OXO-, COMPD. WITH 2,2'-IMINODIETHANOL

Common Name

English

IODOPYRACET I 131 [USAN]

Common Name

English

3,5-DIIODO-131I-4-OXO-1(4H)-PYRIDINEACETIC ACID, COMPOUND WITH 2,2'-IMINODIETHANOL (1:1)

Common Name

English

IODOPYRACET I 131

Official Name

English

Code System Code Type Description

PUBCHEM

23724927