IGANIDIPINE DIHYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C28H38N4O6.2ClH
Molecular Weight	599.546
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of IGANIDIPINE DIHYDROCHLORIDE

Structure Search

SMILES

Cl.Cl.COC(=O)C1=C(C)NC(C)=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OCC(C)(C)CN3CCN(CC=C)CC3

InChI

InChIKey=PJGTYHKZUAHNHC-UHFFFAOYSA-N

InChI=1S/C28H38N4O6.2ClH/c1-7-11-30-12-14-31(15-13-30)17-28(4,5)18-38-27(34)24-20(3)29-19(2)23(26(33)37-6)25(24)21-9-8-10-22(16-21)32(35)36;;/h7-10,16,25,29H,1,11-15,17-18H2,2-6H3;2*1H

HIDE SMILES / InChI

Molecular Formula	C28H38N4O6
Molecular Weight	526.6245
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.chemdrug.com/article/8/3285/16420800.html

Iganidipin is a new dihydropiridynic derivative of calcium antagonist. It is the only currently available calcium antagonist in the form of ophthalmic solution. Its topical administration increases ipsilateral optic nerve head blood flow in rabbits and monkeys and inhibits the contraction of blood vessels induced by endothelin -1. Iganidipin is also used for treat Angina pectoris and Hypertension.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Voltage-gated calcium channel 37 Target ID: CHEMBL2363032 Sources: http://www.ncbi.nlm.nih.gov/pubmed/7575741	Blocker 537

Conditions

Condition	Modality	Highest Phase	Product
Glaucoma 57 Sources: http://www.ncbi.nlm.nih.gov/pubmed/19902393	Primary	Basic research	Unknown Approved Use Unknown
Angina pectoris 106 Sources: http://www.chemdrug.com/article/8/3285/16420800.html	Primary	Phase II 1132	Unknown Approved Use Unknown
Hypertension 567 Sources: http://www.chemdrug.com/article/8/3285/16420800.html	Primary	Withdrawn	Unknown Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY510597	https://www.001chemical.com/chem/119687-33-1
BLD Pharm	BD134328	http://www.bldpharm.com/products/119687-33-1.html
CSNpharm	CSN21683	https://www.csnpharm.com/products/iganidipine.html
Chem Scene	CS-6635	http://www.chemscene.com/119687-33-1.html
MedChem Express	HY-101685	https://www.medchemexpress.com/Iganidipine.html
Molcore	MC510597	https://www.molcore.com/product/119687-33-1
MuseChem	M020797	https://www.musechem.com/product/M020797.html
Smolecule	S580511	https://www.smolecule.com/products/s580511
THE BioTek	bt-368216	https://www.thebiotek.com/product/others/bt-368216
eNovation Chemicals	D677200	https://www.enovationchem.com/ProductDetails.asp?ProductID=D677200

PubMed

Title	Date	PubMed
Neuroprotective effect of calcium channel blocker against retinal ganglion cell damage under hypoxia.	2006 Feb 3	16413513

Patents

Sample Use Guides

In Vivo Use Guide

for rabbit: (14)C-iganidipine solution (0.03%, 30 microL) was instilled into one eye

Route of Administration: Topical

In Vitro Use Guide

Iganidipine (0.01-1 microM) increased the retinal ganglion cells (RGC) viability

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:12:36 GMT 2023` Edited by `admin` on `Sat Dec 16 05:12:36 GMT 2023`
Record UNII	VEE2U6QF71
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

IGANIDIPINE DIHYDROCHLORIDE

Common Name

English

3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-, 3-(2,2-DIMETHYL-3-(4-(2-PROPEN-1-YL)-1-PIPERAZINYL)PROPYL) 5-METHYL ESTER, HYDROCHLORIDE (1:2)

Common Name

English

NKY-722

Code

English

KIRENIDIPINE HYDROCHLORIDE

Common Name

English

KIRENIDIPINE DIHYDROCHLORIDE

Common Name

English

3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-, 2,2-DIMETHYL-3-(4-(2-PROPENYL)-1-PIPERAZINYL)PROPYL METHYL ESTER, DIHYDROCHLORIDE

Common Name

English

KIRENIDIPINE HYDROCHLORIDE [JAN]

Common Name

English

Code System Code Type Description

PUBCHEM

164031

Created by admin on Sat Dec 16 05:12:37 GMT 2023 , Edited by admin on Sat Dec 16 05:12:37 GMT 2023

PRIMARY

CAS

117241-46-0

Created by admin on Sat Dec 16 05:12:37 GMT 2023 , Edited by admin on Sat Dec 16 05:12:37 GMT 2023

PRIMARY

EPA CompTox

DTXSID40922373

Created by admin on Sat Dec 16 05:12:37 GMT 2023 , Edited by admin on Sat Dec 16 05:12:37 GMT 2023

PRIMARY

FDA UNII

VEE2U6QF71

Created by admin on Sat Dec 16 05:12:37 GMT 2023 , Edited by admin on Sat Dec 16 05:12:37 GMT 2023

PRIMARY

Related Record Type Details


					9FPE98DLZ5

IGANIDIPINE

PARENT -> SALT/SOLVATE

Related Record Type Details


					9FPE98DLZ5

IGANIDIPINE

ACTIVE MOIETY

Details

SMILES

InChI

DescriptionSources: http://www.chemdrug.com/article/8/3285/16420800.html

Originator

Approval Year

Targets

Conditions

Approved Use

Approved Use

Approved Use

Sourcing

PubMed

Patents

Sample Use Guides

Description
Sources: http://www.chemdrug.com/article/8/3285/16420800.html