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Details

Stereochemistry RACEMIC
Molecular Formula C10H15N2O2S.Na
Molecular Weight 250.293
Optical Activity ( + / - )
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of THIOBUTABARBITAL SODIUM

SMILES

[Na+].CCC(C)C1(CC)C(=O)NC(=S)[N-]C1=O

InChI

InChIKey=SLZHLQUFNFXTHB-UHFFFAOYSA-M
InChI=1S/C10H16N2O2S.Na/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14;/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15);/q;+1/p-1

HIDE SMILES / InChI
Molecular Formula C10H16N2O2S
Molecular Weight 228.311
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )
Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Thiobutabarbital is a barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant and hypnotic effects, it is used in veterinary medicine for induction in surgical anaesthesia. Thiobutabarbital was formerly used as anesthetic Inactin. ‘Inactin’ (sodium thiobutabarbital) produces smooth induction of anaesthesia after intravenous administration and has a prolonged duration of action. It has variable analgesic activity.

CNS Activity

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
 1.0 mM [IC50]
Inhibitor
8297
 1.0 mM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Inactin

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Enhanced intestinal motility influences absorption in anaesthetized rat.
2001 Jun
Renal interstitial fluid concentrations of angiotensins I and II in anesthetized rats.
2002 Jan
Chemoprophylaxis of transfusion-transmitted agents in labile blood components.
2002 Jul-Aug
Brevenal is a natural inhibitor of brevetoxin action in sodium channel receptor binding assays.
2004 Aug
Glucose-induced time-dependent potentiation of insulin release, but not islet blood perfusion, in anesthetized rats.
2008
Antenatal Corticosteroids and Postnatal Fluid Restriction Produce Differential Effects on AQP3 Expression, Water Handling, and Barrier Function in Perinatal Rat Epidermis.
2010
Gastric emptying of enterally administered liquid meal in conscious rats and during sustained anaesthesia.
2010 Feb
Patents

Patents

US6562363
4
US6638528
14
WO2009151744A1
2

Sample Use Guides

In Vivo Use Guide
Male Wistar rats (8 to 10 weeks old) were anesthetized with thiobutabarbital (120 mg/kg, intraperitoneally (i.p.)).
Route of Administration: Intraperitoneal
In Vitro Use Guide
Thiobutabarbital inhibits hexose transport in cultured 3T3-C2 cells with IC50 value of 1.0 mM.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:09:56 GMT 2023
Edited
by admin
on Fri Dec 15 15:09:56 GMT 2023
Record UNII
VE5XWZ299Q
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
THIOBUTABARBITAL SODIUM
VANDF   WHO-DD  
Common Name English
5-SEC-BUTYL-5-ETHYL-2-THIOBARBITURIC ACID, SODIUM SALT
Common Name English
Thiobutabarbital sodium [WHO-DD]
Common Name English
THIOBUTABARBITAL SODIUM SALT
MI  
Common Name English
THIOBUTABARBITAL SODIUM SALT [MI]
Common Name English
5-ETHYL-5-(1-METHYLPROPYL)-2-THIOBARBITURIC ACID, SODIUM SALT
Common Name English
SODIUM THIOBUTABARBITAL
Common Name English
THIBUTABARBITAL SODIUM
Common Name English
THIOBUTABARBITAL SODIUM [VANDF]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C67084
Created by admin on Fri Dec 15 15:09:56 GMT 2023 , Edited by admin on Fri Dec 15 15:09:56 GMT 2023
Code System Code Type Description
MERCK INDEX
m10746
Created by admin on Fri Dec 15 15:09:56 GMT 2023 , Edited by admin on Fri Dec 15 15:09:56 GMT 2023
PRIMARY Merck Index
FDA UNII
VE5XWZ299Q
Created by admin on Fri Dec 15 15:09:56 GMT 2023 , Edited by admin on Fri Dec 15 15:09:56 GMT 2023
PRIMARY
EPA CompTox
DTXSID40915366
Created by admin on Fri Dec 15 15:09:56 GMT 2023 , Edited by admin on Fri Dec 15 15:09:56 GMT 2023
PRIMARY
RXCUI
314874
Created by admin on Fri Dec 15 15:09:56 GMT 2023 , Edited by admin on Fri Dec 15 15:09:56 GMT 2023
PRIMARY RxNorm
SMS_ID
100000076996
Created by admin on Fri Dec 15 15:09:56 GMT 2023 , Edited by admin on Fri Dec 15 15:09:56 GMT 2023
PRIMARY
PUBCHEM
15086288
Created by admin on Fri Dec 15 15:09:56 GMT 2023 , Edited by admin on Fri Dec 15 15:09:56 GMT 2023
PRIMARY
ECHA (EC/EINECS)
213-425-3
Created by admin on Fri Dec 15 15:09:56 GMT 2023 , Edited by admin on Fri Dec 15 15:09:56 GMT 2023
PRIMARY
CAS
947-08-0
Created by admin on Fri Dec 15 15:09:56 GMT 2023 , Edited by admin on Fri Dec 15 15:09:56 GMT 2023
PRIMARY
EVMPD
SUB15534MIG
Created by admin on Fri Dec 15 15:09:56 GMT 2023 , Edited by admin on Fri Dec 15 15:09:56 GMT 2023
PRIMARY
NCI_THESAURUS
C87671
Created by admin on Fri Dec 15 15:09:56 GMT 2023 , Edited by admin on Fri Dec 15 15:09:56 GMT 2023
PRIMARY
NIH
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