Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C44H69N5O11 |
| Molecular Weight | 844.0456 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 14 / 14 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12O[C@](O)([C@H](C)C[C@@H]1OC)C(=O)C(=O)N3CCCC[C@@]3([H])C(=O)O[C@@H]([C@H](C)[C@@H](O)CC(=O)[C@H](CC)\C=C(C)\C[C@H](C)C[C@@H]2OC)C(\C)=C\[C@@H]4CC[C@@H]([C@@H](C4)OC)N5C=NN=N5
InChI
InChIKey=HIEKJRVYXXINKH-ADVKXBNGSA-N
InChI=1S/C44H69N5O11/c1-10-31-18-25(2)17-26(3)19-37(57-8)40-38(58-9)21-28(5)44(55,60-40)41(52)42(53)48-16-12-11-13-33(48)43(54)59-39(29(6)34(50)23-35(31)51)27(4)20-30-14-15-32(36(22-30)56-7)49-24-45-46-47-49/h18,20,24,26,28-34,36-40,50,55H,10-17,19,21-23H2,1-9H3/b25-18+,27-20+/t26-,28+,29+,30-,31+,32-,33-,34-,36+,37-,38-,39+,40+,44+/m0/s1
| Molecular Formula | C44H69N5O11 |
| Molecular Weight | 844.0456 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 14 / 14 |
| E/Z Centers | 1 |
| Optical Activity | UNSPECIFIED |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:27:41 GMT 2023
by
admin
on
Sat Dec 16 10:27:41 GMT 2023
|
| Record UNII |
VE47C8J10O
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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ABT-281
Created by
admin on Sat Dec 16 10:27:41 GMT 2023 , Edited by admin on Sat Dec 16 10:27:41 GMT 2023
|
PRIMARY | ABT-281 was found to have a shorter duration of action after i.v. dosing in monkeys using an ex vivo whole blood IL-2 production assay. Systemic potency was reduced by 30-fold or more in rat popliteal lymph node hyperplasia and contact hypersensitivity assays. Following i.v. or i.p. administration in the swine contact hypersensitivity model, ABT-281 was 19- and 61-fold less potent, respectively, than FK506. Pharmacokinetic studies showed that ABT-281 had a shorter half life and higher rate of clearance than FK506 in all three species. | ||
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9919023
Created by
admin on Sat Dec 16 10:27:41 GMT 2023 , Edited by admin on Sat Dec 16 10:27:41 GMT 2023
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PRIMARY | |||
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148147-65-3
Created by
admin on Sat Dec 16 10:27:41 GMT 2023 , Edited by admin on Sat Dec 16 10:27:41 GMT 2023
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PRIMARY | |||
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VE47C8J10O
Created by
admin on Sat Dec 16 10:27:41 GMT 2023 , Edited by admin on Sat Dec 16 10:27:41 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |
