MORPHOLINYLMERCAPTOBENZOTHIAZOLE

US Approved Allergenic Extract (1994)

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H12N2OS2
Molecular Weight	252.356
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MORPHOLINYLMERCAPTOBENZOTHIAZOLE

Structure Search

SMILES

C1CN(CCO1)SC2=NC3=C(S2)C=CC=C3

InChI

InChIKey=MHKLKWCYGIBEQF-UHFFFAOYSA-N

InChI=1S/C11H12N2OS2/c1-2-4-10-9(3-1)12-11(15-10)16-13-5-7-14-8-6-13/h1-4H,5-8H2

HIDE SMILES / InChI

Molecular Formula	C11H12N2OS2
Molecular Weight	252.356
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/18845111
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/3180764 and https://www.smartpracticecanada.com/spcanada/pdfs/all-allergens/RC294.pdf

Morpholinylmercaptobenzothiazole is a chemical allergen, it is used in the vulcanization of rubber. It is used for diagnosis of contact allergy. It is a component of Mercapto Mix, used in the epicutaneous patch test, called T.R.U.E. TEST, approved by FDA in 1994. T.R.U.E. TEST is indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Allergic contact dermatitis 14 Sources: http://www.fda.gov/downloads/BiologicsBloodVaccines/Allergenics/UCM294327.pdf	Diagnostic		Approved 8583	T.R.U.E. TEST Approved Use T.R.U.E. TEST is an epicutaneous patch test indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels. Launch Date 1993

Doses

Dose	Population	Adverse events
0.5 % single, topical Recommended Dose: 0.5 % Route: topical Route: single Dose: 0.5 % Sources: https://pubmed.ncbi.nlm.nih.gov/8335734/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/8335734/	Other AEs: Contact dermatitis... Other AEs: Contact dermatitis (1%) Sources: https://pubmed.ncbi.nlm.nih.gov/8335734/

AEs

AE	Significance	Dose	Population
Contact dermatitis	1%	0.5 % single, topical Recommended Dose: 0.5 % Route: topical Route: single Dose: 0.5 % Sources: https://pubmed.ncbi.nlm.nih.gov/8335734/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/8335734/

PubMed

Title	Date	PubMed
Patch test results with the metalworking fluid series of the German Contact Dermatitis Research Group (DKG).	2004-09	15479200
Stability of the mercaptobenzothiazole compounds.	1993-01	8428441
Comparative studies of the sensitization potential of morpholine, 2-mercaptobenzothiazole and 2 of their derivatives in guinea pigs.	1988-07	3180764

Patents

Sample Use Guides

In Vivo Use Guide

Apply the three adhesive panels of allergens and allergen mixes on healthy skin of the back. Remove panels and evaluate the skin 48 hours after application. Re-evaluate the skin 72 to 96 hours after application.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:02:46 GMT 2025` Edited by `admin` on `Mon Mar 31 18:02:46 GMT 2025`
Record UNII	VCD7623F3K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MORPHOLINYLMERCAPTOBENZOTHIAZOLE

Systematic Name

English

2-(4-MORPHOLINO)THIOBENZOTHIAZOLE

Preferred Name

English

N-OXYDIETHYLENE-2-BENZOTHIAZYLSULFENAMIDE

Common Name

English

SULFENAMIDE M

Brand Name

English

NSC-70078

Code

English

N-(OXYDIETHYLENE)BENZOTHIAZOLE-2-SULFENAMIDE

Common Name

English

MORPHOLINYLMERCAPTO-BENZO-THIAZOLE

Systematic Name

English

4-(1,3-BENZOTHIAZOL-2-YLSULFANYL)MORPHOLINE

Systematic Name

English

2-(4-MORPHOLINO)THIOBENZOTHIAZOLE [HSDB]

Common Name

English

ACCEL NS

Brand Name

English

MERAMID M

Brand Name

English

Classification Tree Code System Code

NDF-RT

N0000185508