U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 19:16:42 GMT 2023
Edited
by admin
on Sat Dec 16 19:16:42 GMT 2023
Source Materials Class ORGANISM
Source Materials Type AUTOLOGOUS HUMAN
Source Materials Parent
Part BLOOD
Fraction Material Type CELL
Fraction Name CD4/CD8 enriched T cell fragment
Record UNII
VBZ33SRC28
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Besvatresgene Autoleucel
INN  
Official Name English
besvatresgene autoleucel [INN]
Common Name English
autologous T lymphocytes obtained from peripheral blood lymphocytes by leukapheresis transduced with a self-inactivating, non-replicating lentiviral vector encoding an affinity-enhanced cancer testis antigen (NY-ESO-1 c259 ) specific T-cell receptor (TCR
Common Name English
Code System Code Type Description
NCI_THESAURUS
C199004
Created by admin on Sat Dec 16 19:16:42 GMT 2023 , Edited by admin on Sat Dec 16 19:16:42 GMT 2023
PRIMARY
FDA UNII
VBZ33SRC28
Created by admin on Sat Dec 16 19:16:42 GMT 2023 , Edited by admin on Sat Dec 16 19:16:42 GMT 2023
PRIMARY
INN
12537
Created by admin on Sat Dec 16 19:16:42 GMT 2023 , Edited by admin on Sat Dec 16 19:16:42 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
LENTIVIRAL TRANSFECTION Besvatresgene autoleucel lentiviral vector XLV5D8LY3P

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN Cluster of differentiation 8α 3JY547656H
VECTOR EXPRESSED PROTEIN Besvatresgene autoleucel expressed preprotein RFU39XY2EN
INSERTED GENE EXPRESSION VECTOR Besvatresgene autoleucel transgene insert 7BR8NV2HGY
VECTOR EXPRESSED PROTEIN Besvatresgene autoleucel expressed T-cell receptor TU89AG8SPJ