Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C11H17O4PS2 |
| Molecular Weight | 308.354 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOP(=S)(OCC)OC1=CC=C(C=C1)[S+](C)[O-]
InChI
InChIKey=XDNBJTQLKCIJBV-UHFFFAOYSA-N
InChI=1S/C11H17O4PS2/c1-4-13-16(17,14-5-2)15-10-6-8-11(9-7-10)18(3)12/h6-9H,4-5H2,1-3H3
| Molecular Formula | C11H17O4PS2 |
| Molecular Weight | 308.354 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Fensulfothion is an organophosphate insecticide/nematicide. Fensulfothion is highly toxic to man and other non-target terrestrial and aquatic organisms from acute oral and dermal routes of exposure. Fensulfothion is registered for use as preplant or at-planting soil application to tobacco and various fruits and vegetables. Postplant topical applications are permitted in addition to the at-planting application on corn, peanuts, and rutabagas. Topical application is also permitted on commercial and ornamental turf. Fensulfothion is an organophosphate insecticide/nematicide that kills primarily by contact action, but also provides some systemic control of insects attacking the foliage of treated plants. The mode of action is by phosphorylating the acetylcholinesterase enzyme of tissues, allowing accumulation of acetylcholine at nerve junctions, with subsequent blocking effects upon the central nervous system.
CNS Activity
Sources: http://pmep.cce.cornell.edu/profiles/insect-mite/fenitrothion-methylpara/fensulfothion/insect-prof-fensulfothion.html
Curator's Comment: The mode of action is by phosphorylating the acetylcholinesterase enzyme of tissues, allowing accumulation of acetylcholine at nerve junctions, with subsequent blocking effects upon the central nervous system.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Livestock drugs and disease: the fatal combination behind breeding failure in endangered bearded vultures. | 2010-11-30 |
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| Separation of organophosphorus pesticides by using nano-liquid chromatography. | 2009-05-01 |
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| Longitudinal trends in organophosphate incidents reported to the National Pesticide Information Center, 1995-2007. | 2009-04-20 |
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| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006-11 |
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| Continuous flow microextraction combined with high-performance liquid chromatography for the analysis of pesticides in natural waters. | 2006-07-28 |
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| High-performance liquid chromatographic separation of the enantiomers of organophosphorus pesticides on polysaccharide chiral stationary phases. | 2001-09-14 |
Patents
Sample Use Guides
Fensulfothion is used against soil nematodes (free living, root knot and cyst forming nematodes) and a broad spectrum of soil borne insects in field crops, vegetables and fruit. It is also used against nematodes in turf grasses, in flowers and in ornamentals. Fensulfothion is highly toxic to man and other non-target terrestrial and aquatic organisms from acute oral and dermal routes of exposure.
Route of Administration:
Unknown
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/143857
The effect of fensulfothion at four concentrations (1, 5, 25, and 125 ppm) was tested on the growth of five bacteria, Agrobacterium tumefaciens, Corynebacterium fascians, Erwinia carotovora, Pseudomonas solanacearum, and Streptomyces scabies and four fungi, Fusarium oxysporum f. sp. vasinfectum, Fusarium solani, Rhizoctonia solani, and Sclerotium bataticola.
| Substance Class |
Chemical
Created
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Edited
Mon Mar 31 17:51:32 GMT 2025
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Mon Mar 31 17:51:32 GMT 2025
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| Record UNII |
VB39B105PO
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| Record Status |
Validated (UNII)
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EPA PESTICIDE CODE |
32701
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C073264
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FENSULFOTHION
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fensulfothion
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| Related Record | Type | Details | ||
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METABOLITE -> PARENT |
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