Precemtabart Tocentecan

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 12:02:58 GMT 2025` Edited by `admin` on `Wed Apr 02 12:02:58 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	V97BV45YBZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

M-9140

Preferred Name

English

Precemtabart Tocentecan

Official Name

English

precemtabart tocentecan [INN]

Common Name

English

Immunoglobulin G1 [235-proline,236-valine,237-alanine,331-serine,332-serine,de-448-lysine], anti-(human carcinoembryonic antigen-related cell adhesion molecule 5) (human monoclonal MBE-748 ?1-chain), complex with human monoclonal MBE-748 ?-chain, dimer,

Common Name

English

M9140

Code

English

immunoglobulin G1-kappa, anti-[Homo sapiens CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5, CEA, CD66e)], Homo sapiens monoclonal antibody, conjugated on an average of 8 cysteinyl residues to tocentecan, comprising a linker and a camp

Common Name

English

Code System Code Type Description

CAS

2873366-83-5

Created by admin on Wed Apr 02 12:02:58 GMT 2025 , Edited by admin on Wed Apr 02 12:02:58 GMT 2025

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SMS_ID

300000043402

Created by admin on Wed Apr 02 12:02:58 GMT 2025 , Edited by admin on Wed Apr 02 12:02:58 GMT 2025

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NCI_THESAURUS

C189819

Created by admin on Wed Apr 02 12:02:58 GMT 2025 , Edited by admin on Wed Apr 02 12:02:58 GMT 2025

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INN

13008

Created by admin on Wed Apr 02 12:02:58 GMT 2025 , Edited by admin on Wed Apr 02 12:02:58 GMT 2025

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FDA UNII

V97BV45YBZ

Created by admin on Wed Apr 02 12:02:58 GMT 2025 , Edited by admin on Wed Apr 02 12:02:58 GMT 2025

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From	To
1_22	1_97
2_22	2_97
2_146	2_202
2_222	4_214
2_262	2_322
1_146	1_202
2_368	2_426
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_222	3_214
1_228	2_228
1_231	2_231
1_262	1_322
1_368	1_426

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					V97BV45YBZ

Precemtabart Tocentecan

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_222] [1_228] [1_231] [2_222] [2_228] [2_231] [3_214] [4_214]		C	Amount:	Cysteinyl M-9140 drug-linker	493THJ7H74

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL