Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H34O6 |
| Molecular Weight | 370.4804 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 2 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCC[C@H](O)\C=C\[C@@H](O)[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC=O
InChI
InChIKey=FMNQRUKVXAQEAZ-JNRFBPFXSA-N
InChI=1S/C20H34O6/c1-2-3-6-9-16(22)12-13-18(23)17(19(24)14-15-21)10-7-4-5-8-11-20(25)26/h4,7,12-13,15-19,22-24H,2-3,5-6,8-11,14H2,1H3,(H,25,26)/b7-4-,13-12+/t16-,17+,18+,19-/m0/s1
| Molecular Formula | C20H34O6 |
| Molecular Weight | 370.4804 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 2 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Plasma levels and urinary excretion of prostaglandins in patients with rheumatoid arthritis. | 1983 Dec |
|
| Experimental traumatic brain injury elevates brain prostaglandin E2 and thromboxane B2 levels in rats. | 1988 |
|
| Effects of current therapy of Kawasaki disease on eicosanoid metabolism. | 1988 Jun 1 |
|
| Effects of sulfasalazine and a sulfasalazine analogue on the formation of lipoxygenase and cyclooxygenase products. | 1989 Oct 10 |
|
| The effects of bicarbonate and acetate haemodialysis on platelet cyclic AMP concentration, thromboxane B2 release and aggregation. | 1991 May |
|
| Effects of diltiazem on thromboxane B2 production from platelet-rich plasma and whole blood. | 1991 Nov |
|
| High-performance liquid chromatographic assay of platelet-produced thromboxane B2. | 1993 Jan 29 |
|
| Generation of 8-epiprostaglandin F2alpha by human monocytes. Discriminate production by reactive oxygen species and prostaglandin endoperoxide synthase-2. | 1996 Apr 12 |
|
| Wines and grape juices as modulators of platelet aggregation in healthy human subjects. | 1996 Mar 15 |
|
| Consumption of ginger (Zingiber officinale roscoe) does not affect ex vivo platelet thromboxane production in humans. | 1996 Nov |
|
| Concomitant in vitro platelet hypofunction and increased thromboxane B2 (TXB2) generation and enhanced in vivo platelet activation. A distinct syndrome in thrombosis? | 1997 Oct |
|
| Measurement of thromboxane B2 in platelet-rich human plasma by gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry following extractive pentafluorobenzyl esterification. | 1998 Jul 15 |
|
| Plasma thromboxane B2 concentration in patients with ventricular septal defect and pulmonary hypertension. | 1998 Mar |
|
| Comparison of in vitro-activity of commonly used topical glucocorticoids on cytokine- and phospholipase inhibition. | 2004 Aug 31 |
|
| Increased renal production of angiotensin II and thromboxane B2 in conscious diabetic rats. | 2005 Apr |
|
| Transfer of very low density lipoprotein-associated phospholipids to activated human platelets. | 2006 Feb |
|
| The thromboxane receptor antagonist S18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein E-deficient mice. | 2006 Jan |
|
| NMDA-induced seizure intensity is enhanced in COX-2 deficient mice. | 2008 Nov |
|
| The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase. | 2010 Mar |
|
| Induction of hemeoxygenase-1 attenuates the hypertension and renal inflammation in spontaneously hypertensive rats. | 2010 Nov |
|
| Role of cyclooxygenase-2 in exacerbation of allergen-induced airway remodeling by multiwalled carbon nanotubes. | 2013 Oct |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:47:24 UTC 2023
by
admin
on
Sat Dec 16 08:47:24 UTC 2023
|
| Record UNII |
V94M3R26ZV
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C879
Created by
admin on Sat Dec 16 08:47:24 UTC 2023 , Edited by admin on Sat Dec 16 08:47:24 UTC 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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Thromboxane B2
Created by
admin on Sat Dec 16 08:47:24 UTC 2023 , Edited by admin on Sat Dec 16 08:47:24 UTC 2023
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76956381
Created by
admin on Sat Dec 16 08:47:24 UTC 2023 , Edited by admin on Sat Dec 16 08:47:24 UTC 2023
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C107560
Created by
admin on Sat Dec 16 08:47:24 UTC 2023 , Edited by admin on Sat Dec 16 08:47:24 UTC 2023
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V94M3R26ZV
Created by
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28728
Created by
admin on Sat Dec 16 08:47:24 UTC 2023 , Edited by admin on Sat Dec 16 08:47:24 UTC 2023
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m10812
Created by
admin on Sat Dec 16 08:47:24 UTC 2023 , Edited by admin on Sat Dec 16 08:47:24 UTC 2023
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90696
Created by
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DTXSID60903947
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54397-85-2
Created by
admin on Sat Dec 16 08:47:24 UTC 2023 , Edited by admin on Sat Dec 16 08:47:24 UTC 2023
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PRIMARY |
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