THROMBOXANE B2

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H34O6
Molecular Weight	370.4811
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	2
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCC[C@H](O)\C=C\[C@@H](O)[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC=O

InChI

InChIKey=FMNQRUKVXAQEAZ-JNRFBPFXSA-N

InChI=1S/C20H34O6/c1-2-3-6-9-16(22)12-13-18(23)17(19(24)14-15-21)10-7-4-5-8-11-20(25)26/h4,7,12-13,15-19,22-24H,2-3,5-6,8-11,14H2,1H3,(H,25,26)/b7-4-,13-12+/t16-,17+,18+,19-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C20H34O6
Molecular Weight	370.4811
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	2
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Role of cyclooxygenase-2 in exacerbation of allergen-induced airway remodeling by multiwalled carbon nanotubes.	2013-10	23642096
Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo.	2011-01-15	20933508
Induction of hemeoxygenase-1 attenuates the hypertension and renal inflammation in spontaneously hypertensive rats.	2010-11	20667508
The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.	2010-03	19934399
NMDA-induced seizure intensity is enhanced in COX-2 deficient mice.	2008-11	18834901
Transfer of very low density lipoprotein-associated phospholipids to activated human platelets.	2006-02	16293890
The thromboxane receptor antagonist S18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein E-deficient mice.	2006-01	16380483
Increased renal production of angiotensin II and thromboxane B2 in conscious diabetic rats.	2005-04	15831366
Comparison of in vitro-activity of commonly used topical glucocorticoids on cytokine- and phospholipase inhibition.	2004-08-31	15337628
Role of endothelin-1 and thromboxane A2 in the pulmonary hypertension induced by heparin-protamine interaction in anesthetized dogs.	2004-01	14668575
Meloxicam, 15 mg/day, spares platelet function in healthy volunteers.	1999-10	10546927
Measurement of thromboxane B2 in platelet-rich human plasma by gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry following extractive pentafluorobenzyl esterification.	1998-07-15	9683522
Plasma thromboxane B2 concentration in patients with ventricular septal defect and pulmonary hypertension.	1998-03	9583446
Concomitant in vitro platelet hypofunction and increased thromboxane B2 (TXB2) generation and enhanced in vivo platelet activation. A distinct syndrome in thrombosis?	1997-10	9338626
Consumption of ginger (Zingiber officinale roscoe) does not affect ex vivo platelet thromboxane production in humans.	1996-11	8933126
Generation of 8-epiprostaglandin F2alpha by human monocytes. Discriminate production by reactive oxygen species and prostaglandin endoperoxide synthase-2.	1996-04-12	8621535
Wines and grape juices as modulators of platelet aggregation in healthy human subjects.	1996-03-15	8814965
Plasma thromboxane B2 concentration in pulmonary hypertension associated with congenital heart disease.	1994-12	7994842
Relative contributions of direct and indirect mechanisms mediating endothelin-induced contraction of guinea-pig trachea.	1993-11	7507780
Platelet-derived growth factor release and antiplatelet treatment with low-dose acetylsalicylic acid.	1993-08	8342880
High-performance liquid chromatographic assay of platelet-produced thromboxane B2.	1993-01-29	8454699
[The effect of indomethacin and leukinferon on the level of blood plasma thromboxane B2, platelet aggregation and the immune system of patients with endometrial cancer in the perioperative period].	1992-03-01	1416192
Effects of diltiazem on thromboxane B2 production from platelet-rich plasma and whole blood.	1991-11	1808624
The effects of bicarbonate and acetate haemodialysis on platelet cyclic AMP concentration, thromboxane B2 release and aggregation.	1991-05	1651098
Effects of sulfasalazine and a sulfasalazine analogue on the formation of lipoxygenase and cyclooxygenase products.	1989-10-10	2572437
Effects of current therapy of Kawasaki disease on eicosanoid metabolism.	1988-06-01	2454025
Experimental traumatic brain injury elevates brain prostaglandin E2 and thromboxane B2 levels in rats.	1988	3249309
Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis.	1985-01	4038407
Plasma levels and urinary excretion of prostaglandins in patients with rheumatoid arthritis.	1983-12	6589104

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:18:57 GMT 2025` Edited by `admin` on `Mon Mar 31 22:18:57 GMT 2025`
Record UNII	V94M3R26ZV
Record Status	`FAILED`
Record Version

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Name

Type

Language

THROMBOXANE B2

Common Name

English

PHD

Preferred Name

English

THROMBOXANE B2 [MI]

Common Name

English

TXB2

Common Name

English

5-HEPTENOIC ACID, 7-((2R,3S,4S)-TETRAHYDRO-4,6-DIHYDROXY-2-((1E,3S)-3-HYDROXY-1-OCTEN-1-YL)-2H-PYRAN-3-YL)-, (5Z)-

Systematic Name

English

(5Z,9.ALPHA.,13E,15S)-9,11,15-TRIHYDROXYTHROMBOXA-5,13-DIEN-1-OIC ACID

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C879