Nefonadogene vonzuparvovec transgene insert

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 20:20:58 GMT 2025` Edited by `admin` on `Wed Apr 02 20:20:58 GMT 2025`
Nucleic Acid Type	VECTOR
Sequence Origin	VIRAL, HUMAN
Sequence Type	COMPLETE
Record UNII	V7ZD8WVA5S
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Nefonadogene vonzuparvovec transgene insert encoding human heme A farnesyltransferase gene COX10 mitochondrial targeting signal peptide fusion with human mitochondria NADH dehydrogenase subunit 1 codon-optimized gene plus heme A farnesyltransferase gene

Preferred Name

English

Nefonadogene vonzuparvovec transgene insert

Common Name

English

Code System Code Type Description

FDA UNII

V7ZD8WVA5S

Created by admin on Wed Apr 02 20:20:58 GMT 2025 , Edited by admin on Wed Apr 02 20:20:58 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_1-1_3952	3952 / 3952

Linkage	Site Range	Site Count
Phosphate	1_2-1_3952	3951 / 3951

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
CMV promoter	NUCLEIC ACID FEATURE

SV40 poly(A)	NUCLEIC ACID FEATURE

3' UTR	NUCLEIC ACID FEATURE

CMV enhancer	NUCLEIC ACID FEATURE

codon-optimised human NADH dehydrogenase subunit 1 (ND1)	NUCLEIC ACID FEATURE

Mitochondrial targeting sequence (MTS) from human heme A farnesyltransferase gene (COX10)	NUCLEIC ACID FEATURE

Chimeric intron	NUCLEIC ACID FEATURE

Kozak sequence	NUCLEIC ACID FEATURE

AAV2 ITR	NUCLEIC ACID FEATURE