BETIFISOLIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 13:50:08 GMT 2025` Edited by `admin` on `Wed Apr 02 13:50:08 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	V7XRB4BO26
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BETIFISOLIMAB

Official Name

English

MSB-2311

Preferred Name

English

betifisolimab [INN]

Common Name

English

MSB2311-HUMANIZED PD-L1 ANTIBODY

Common Name

English

HUMANIZED PD-L1 ANTIBODY (MSB2311)

Common Name

English

MSB2311

Code

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN PROGRAMMED DEATH-LIGAND 1) (HUMAN-MUS MUSCULUS MONOCLONAL MSB2311 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL MSB2311 .KAPPA.-CHAIN, DIMER

Common Name

English

MSB 2311 [WHO-DD]

Common Name

English

Code System Code Type Description

CAS

2460539-60-8

Created by admin on Wed Apr 02 13:50:08 GMT 2025 , Edited by admin on Wed Apr 02 13:50:08 GMT 2025

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FDA UNII

V7XRB4BO26

Created by admin on Wed Apr 02 13:50:08 GMT 2025 , Edited by admin on Wed Apr 02 13:50:08 GMT 2025

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INN

11926

Created by admin on Wed Apr 02 13:50:08 GMT 2025 , Edited by admin on Wed Apr 02 13:50:08 GMT 2025

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NCI_THESAURUS

C155931

Created by admin on Wed Apr 02 13:50:08 GMT 2025 , Edited by admin on Wed Apr 02 13:50:08 GMT 2025

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SMS_ID

300000042090

Created by admin on Wed Apr 02 13:50:08 GMT 2025 , Edited by admin on Wed Apr 02 13:50:08 GMT 2025

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From	To
1_22	1_96
1_146	1_202
1_222	3_218
1_228	2_228
1_231	2_231
1_263	1_323
1_369	1_427
2_22	2_96
2_146	2_202
2_222	4_218
2_263	2_323
2_369	2_427
3_23	3_92
3_138	3_198
4_23	4_92
4_138	4_198

Related Record Type Details


					L4766ELH5T

PROGRAMMED CELL DEATH 1 LIGAND 1

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					V7XRB4BO26

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_449] [2_449]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL