Sonavibart

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 00:17:14 GMT 2025` Edited by `admin` on `Wed Apr 02 00:17:14 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED
Sequence Type	COMPLETE
Record UNII	V7MT9HQR2Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Sonavibart

Official Name

English

VIR-2482

Preferred Name

English

VIR2482

Code

English

SONAVIBART [USAN]

Common Name

English

H-gamma1 heavy chain Homo sapiens (1-458) [VH (Homo sapiens IGHV6-1*01 (95.0%) -(IGHD) -IGHJ3*02 (93.8%), CDR-IMGT [10.9.18] (26-35.53-61.100-117)) (1-128) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v24 CH3 L107, S114 (CH1 R120 (225) (

Common Name

English

sonavibart [INN]

Common Name

English

Immunoglobulin G1 [439-leucine,445-serine], anti-(influenza A virus hemagglutinin) (human monoclonal VIR-2482 ?1-chain), disulfide with human monoclonal VIR-2482 ?-chain, dimer

Common Name

English

immunoglobulin G1-kappa, anti-[influenza A virus hemagglutinin HA], Homo sapiens monoclonal antibody (sonavibart)

Common Name

English

Code System Code Type Description

CAS

2769699-23-0

Created by admin on Wed Apr 02 00:17:14 GMT 2025 , Edited by admin on Wed Apr 02 00:17:14 GMT 2025

PRIMARY

NCI_THESAURUS

C206990

Created by admin on Wed Apr 02 00:17:14 GMT 2025 , Edited by admin on Wed Apr 02 00:17:14 GMT 2025

PRIMARY

FDA UNII

V7MT9HQR2Q

Created by admin on Wed Apr 02 00:17:14 GMT 2025 , Edited by admin on Wed Apr 02 00:17:14 GMT 2025

PRIMARY

USAN

MN-16

Created by admin on Wed Apr 02 00:17:14 GMT 2025 , Edited by admin on Wed Apr 02 00:17:14 GMT 2025

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SMS_ID

300000054789

Created by admin on Wed Apr 02 00:17:14 GMT 2025 , Edited by admin on Wed Apr 02 00:17:14 GMT 2025

PRIMARY

INN

13036

Created by admin on Wed Apr 02 00:17:14 GMT 2025 , Edited by admin on Wed Apr 02 00:17:14 GMT 2025

PRIMARY

From	To
1_22	1_99
1_155	1_211
1_231	3_210
1_237	2_237
1_240	2_240
1_272	1_332
1_378	1_436
2_22	2_99
2_155	2_211
2_231	4_210
2_272	2_332
2_378	2_436
3_23	3_88
3_130	3_190
4_23	4_88
4_130	4_190

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_308
N	2_308

Related Record Type Details


					R9HH0NDE2E

INFLUENZA A VIRUS WHOLE

TARGET ORGANISM->INHIBITOR

Amount:


					56B215N9J9

INFLUENZA A HEMAGGLUTIN

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					V7MT9HQR2Q

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_458] [2_458]	C-TERMINUS	K	Amount:	LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q	Amount:	PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL