LEVOFURALTADONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C13H16N4O6
Molecular Weight	324.2893
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[O-][N+](=O)C1=CC=C(O1)\C=N\N2C[C@H](CN3CCOCC3)OC2=O

InChI

InChIKey=YVQVOQKFMFRVGR-NGPAHMQLSA-N

InChI=1S/C13H16N4O6/c18-13-16(14-7-10-1-2-12(22-10)17(19)20)9-11(23-13)8-15-3-5-21-6-4-15/h1-2,7,11H,3-6,8-9H2/b14-7+/t11-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C13H16N4O6
Molecular Weight	324.2893
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: Woodruff, A.W. (1974) Medicine in the Tropics, page 98, retrieved from: https://books.google.ru/books?id=rJHKbfThDvwC | (1993) Advances in Parasitology, page 33, retrieved from: https://books.google.ru/books?id=gJEckkQ30y4C | http://lib.itg.be/open/ASBMT/1977/1977asbm0475.pdf

Levofuraltadone is the nitrofurane used for the treatment of trypanosomiasis. It has been shown to be effective in mice and polyneuritis, a serious side effect of nitrofurazone therapy, is less frequent with levofuraltadone. Nevertheless, levofuraltadone is a very toxic agent and it has never been commercially produced.

Approval Year

PubMed

Title	Date	PubMed
[Comparison of drug tolerance between nitrofurazone, levofuraltadone (NF-602) and Bay 2502].	1969 Jan-Mar	5365810
[Comparison of the therapeutic tolerance of nitrofurazone, levofuraltadone and the Bay 2502 preparation].	1969 Jan-Mar	4243805

Sample Use Guides

In Vivo Use Guide

30 mg/kg each day for 15 days followed by 10 mg/kg/day for 3 months

Route of Administration: Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:02:26 GMT 2023` Edited by `admin` on `Sat Dec 16 18:02:26 GMT 2023`
Record UNII	V6H66N6UDU
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

LEVOFURALTADONE

Official Name

English

NF-902 FREE BASE

Code

English

NSC-527986

Code

English

LEVOFURALTADON

Common Name

English

NF-602

Code

English

(-)-5-(MORPHOLINOMETHYL)-3-((5-NITROFURFURYLIDENE)AMINO)-2-OXAZOLIDINONE

Systematic Name

English

2-OXAZOLIDINONE, 5-(4-MORPHOLINYLMETHYL)-3-(((5-NITRO-2-FURANYL)METHYLENE)AMINO)-, (5S)-

Systematic Name

English

2-OXAZOLIDINONE, 5-(4-MORPHOLINYLMETHYL)-3-(((5-NITRO-2-FURANYL)METHYLENE)AMINO)-, (-)-

Systematic Name

English

LEVOFURALTADONE [USAN]

Common Name

English

FURALTADONE, (S)-

Common Name

English

levofuraltadone [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C52588