Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | 2C5H6NO3.Mg |
| Molecular Weight | 280.5171 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Mg++].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]2CCC(=O)N2
InChI
InChIKey=JQAACYUZYRBHGG-QHTZZOMLSA-L
InChI=1S/2C5H7NO3.Mg/c2*7-4-2-1-3(6-4)5(8)9;/h2*3H,1-2H2,(H,6,7)(H,8,9);/q;;+2/p-2/t2*3-;/m00./s1
| Molecular Formula | Mg |
| Molecular Weight | 24.305 |
| Charge | 2 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C5H6NO3 |
| Molecular Weight | 128.106 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionSources: http://www.currentscience.ac.in/Volumes/102/02/0288.pdfhttps://www.drugs.com/otc/121041/cleansing-foaming-gel-acne-pro-skin.html | https://www.ncbi.nlm.nih.gov/pubmed/25727335 | https://www.ncbi.nlm.nih.gov/pubmed/21834944 | https://www.ulprospector.com/en/na/PersonalCare/Detail/6637/223524/EcoCare-Zinclean | http://www.scalp-health.com/zinc-pca.htmCurator's Comment: description was created based on several sources, including
http://www.cir-safety.org/sites/default/files/pca.pdf
Sources: http://www.currentscience.ac.in/Volumes/102/02/0288.pdfhttps://www.drugs.com/otc/121041/cleansing-foaming-gel-acne-pro-skin.html | https://www.ncbi.nlm.nih.gov/pubmed/25727335 | https://www.ncbi.nlm.nih.gov/pubmed/21834944 | https://www.ulprospector.com/en/na/PersonalCare/Detail/6637/223524/EcoCare-Zinclean | http://www.scalp-health.com/zinc-pca.htm
Curator's Comment: description was created based on several sources, including
http://www.cir-safety.org/sites/default/files/pca.pdf
Zinc Pidolate (Zinc PCA) is a topical skin product with purifying, astingent, anti-inflammatory, antiseptic activity. It has long been used as a cosmetic ingredient, because of its astringent and anti-microbial properties. Zinc Pidolate has also being shown to be effective against halitosis. Zinc PCA prevents the UV-induced MMP-1 production in vitro by suppressing the activation of AP-1. Zinc PCA was also able to enhance type I collagen synthesis in NHDFs, by increasing the expression of the mRNA encoding the ascorbic acid transporter SVCT2 in non-UV irradiated
NHDFs, which suggests its promising effect against not only photoaged skin but also for the simple atrophic change of intrinsic skin ageing. Zinc PCA is able to suppress sebum secretion by inhibiting 5-α reductase in hyperseborrhea, to suppress body odor by forming zinc salts with short-chain fatty acids, to suppress wrinkles by inhibiting AP-1 to and inhibit bacterial growth including acne related Propionibacterium acnes.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL3271 |
|||
Target ID: P02452|||Q15176|||Q9UML6 Gene ID: 1277.0 Gene Symbol: COL1A1 Target Organism: Homo sapiens (Human) |
|||
Target ID: CHEMBL2111421 |
|||
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Preventing | CLEANSING FOAMING GEL ACNE PRO SKIN- zinc pidolate gel Approved UseLange Gel will turn into foam, during application. It will cleanse skin thoroughly without any dryness effect, in order to avoid hyperseboohea phenomenon, a main cause of acne. Launch Date2012 |
|||
| Primary | Unknown Approved UseUnknown |
|||
| Primary | EcoCare™ Zinclean Approved UseUse in anti-dandruff shampoos |
|||
| Primary | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Electrophilic fluorination of pyroglutamic acid derivatives: application of substrate-dependent reactivity and diastereoselectivity to the synthesis of optically active 4-fluoroglutamic acids. | 2001 Dec 28 |
|
| Massive 5-oxoprolinuria with normal 5-oxoprolinase and glutathione synthetase activities. | 2001 Jun |
|
| Stability and CTL activity of N-terminal glutamic acid containing peptides. | 2001 Jun |
|
| The mechanism of aubstrate eecognition of pyroglutamyl-peptidase I from Bacillus amyloliquefaciens as determined by X-ray crystallography and site-directed mutagenesis. | 2001 May 25 |
|
| Stability and CTL-activity of P40/ELA melanoma vaccine candidate. | 2001 Sep-Dec |
|
| Major outer membrane proteins and proteolytic processing of RgpA and Kgp of Porphyromonas gingivalis W50. | 2002 Apr 1 |
|
| Generation of amyloid beta peptide with pyroglutamate at position 3 in primary cortical neurons. | 2002 Jul 12 |
|
| Two novel antifungal peptides distinct with a five-disulfide motif from the bark of Eucommia ulmoides Oliv. | 2002 Jun 19 |
|
| Methacrylate derivatives incorporating pyroglutamic acid. | 2002 Nov-Dec |
|
| Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity. | 2002 Sep 3 |
|
| Beta-lactams as versatile synthons for homochiral ibotenate analogues with potential for activity at glutamate receptors. | 2003 Aug 7 |
|
| Isolation and identification of indigestible pyroglutamyl peptides in an enzymatic hydrolysate of wheat gluten prepared on an industrial scale. | 2003 Jan 1 |
|
| Characterization of a new bradykinin-potentiating peptide (TmF) from Trimeresurus mucrosquamatus. | 2003 Jul |
|
| Reinvestigation of the proposed folding and self-association of the Neuropeptide Head Activator. | 2003 Mar |
|
| [Evolution of the neuroprotection concept]. | 2003 Mar-Apr |
|
| Human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site. | 2004 Feb 10 |
|
| Identification of endogenous phosphorylation sites of bovine medium and low molecular weight neurofilament proteins by tandem mass spectrometry. | 2004 Feb 24 |
|
| Integrative annotation of 21,037 human genes validated by full-length cDNA clones. | 2004 Jun |
|
| Discrepin, a new peptide of the sub-family alpha-ktx15, isolated from the scorpion Tityus discrepans irreversibly blocks K+ -channels (IA currents) of cerebellum granular cells. | 2004 Oct 15 |
|
| Alpha-tocopherol pro-vitamins: synthesis, hydrolysis and accumulation in rabbit ear skin. | 2004 Oct 19 |
|
| Anuroctoxin, a new scorpion toxin of the alpha-KTx 6 subfamily, is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes. | 2005 Apr |
|
| Stereoselective synthesis of conformationally constrained omega-amino acid analogues from pyroglutamic acid. | 2005 Aug 7 |
|
| Biomarker metabolites capturing the metabolite variance present in a rice plant developmental period. | 2005 May 31 |
|
| CFSUM1 and CFSUM2 in urine from patients with chronic fatigue syndrome are methodological artefacts. | 2006 Feb |
|
| Comparative effect of a new mouthrinse containing chlorhexidine, triclosan and zinc on volatile sulphur compounds: a randomized, crossover, double-blind study. | 2016 Aug |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:36:23 GMT 2023
by
admin
on
Fri Dec 15 16:36:23 GMT 2023
|
| Record UNII |
V5PC588N7G
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
WHO-VATC |
QA12CC08
Created by
admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
|
||
|
WHO-ATC |
A12CC08
Created by
admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
MAGNESIUM PIDOLATE
Created by
admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
|
PRIMARY | |||
|
DBSALT002689
Created by
admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
|
PRIMARY | |||
|
CHEMBL397976
Created by
admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
|
PRIMARY | |||
|
V5PC588N7G
Created by
admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
|
PRIMARY | |||
|
V5PC588N7G
Created by
admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
|
PRIMARY | |||
|
14559042
Created by
admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
|
PRIMARY | |||
|
100000089075
Created by
admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
|
PRIMARY | |||
|
116240
Created by
admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
|
PRIMARY | RxNorm | ||
|
4597
Created by
admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
|
PRIMARY | |||
|
263-365-7
Created by
admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
|
PRIMARY | |||
|
SUB03045MIG
Created by
admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
|
PRIMARY | |||
|
62003-27-4
Created by
admin on Fri Dec 15 16:36:23 GMT 2023 , Edited by admin on Fri Dec 15 16:36:23 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |