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Details

Stereochemistry ABSOLUTE
Molecular Formula 2C5H6NO3.Mg
Molecular Weight 280.5171
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MAGNESIUM PIDOLATE

SMILES

[Mg++].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]2CCC(=O)N2

InChI

InChIKey=JQAACYUZYRBHGG-QHTZZOMLSA-L
InChI=1S/2C5H7NO3.Mg/c2*7-4-2-1-3(6-4)5(8)9;/h2*3H,1-2H2,(H,6,7)(H,8,9);/q;;+2/p-2/t2*3-;/m00./s1

HIDE SMILES / InChI

Molecular Formula Mg
Molecular Weight 24.305
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C5H6NO3
Molecular Weight 128.106
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Zinc Pidolate (Zinc PCA) is a topical skin product with purifying, astingent, anti-inflammatory, antiseptic activity. It has long been used as a cosmetic ingredient, because of its astringent and anti-microbial properties. Zinc Pidolate has also being shown to be effective against halitosis. Zinc PCA prevents the UV-induced MMP-1 production in vitro by suppressing the activation of AP-1. Zinc PCA was also able to enhance type I collagen synthesis in NHDFs, by increasing the expression of the mRNA encoding the ascorbic acid transporter SVCT2 in non-UV irradiated NHDFs, which suggests its promising effect against not only photoaged skin but also for the simple atrophic change of intrinsic skin ageing. Zinc PCA is able to suppress sebum secretion by inhibiting 5-α reductase in hyperseborrhea, to suppress body odor by forming zinc salts with short-chain fatty acids, to suppress wrinkles by inhibiting AP-1 to and inhibit bacterial growth including acne related Propionibacterium acnes.

CNS Activity

Curator's Comment: Known to penetrate blood-brain barrier in rats. Is produced naturally in human brain

Originator

Sources: Haitinger, L.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
CLEANSING FOAMING GEL ACNE PRO SKIN- zinc pidolate gel

Approved Use

Lange Gel will turn into foam, during application. It will cleanse skin thoroughly without any dryness effect, in order to avoid hyperseboohea phenomenon, a main cause of acne.

Launch Date

1.34256958E12
Primary
Unknown

Approved Use

Unknown
Primary
EcoCare™ Zinclean

Approved Use

Use in anti-dandruff shampoos
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Chromosome 13 dementia syndromes as models of neurodegeneration.
2001 Dec
Inhibition of a model protease--pyroglutamate aminopeptidase by a natural oligosaccharide gum from Hakea gibbosa.
2001 Jan 16
In vivo confocal Raman microspectroscopy of the skin: noninvasive determination of molecular concentration profiles.
2001 Mar
Comparison of the positive and negative ion electrospray mass spectra of some small peptides containing pyroglutamate.
2002
Continuous spectrometric assays for glutaminyl cyclase activity.
2002 Apr 1
Major outer membrane proteins and proteolytic processing of RgpA and Kgp of Porphyromonas gingivalis W50.
2002 Apr 1
Stereoselective synthesis of dipeptide beta-turn mimetics: 7-benzyl and 8-phenyl substituted azabicyclo[4.3.0]nonane amino acid esters.
2002 Sep 6
Pressure/temperature combined treatments of precursors yield hormone-like peptides with pyroglutamate at the N terminus.
2003 Dec 31
Solution structure of the cytotoxic RNase 4 from oocytes of bullfrog Rana catesbeiana.
2003 Feb 28
Pyrrolidinones derived from (S)-pyroglutamic acid: penmacric acid and analogues.
2003 Jul 7
[Characteristics of pyrrolidone pharmacokinetics in rats].
2003 Nov-Dec
Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions.
2004 Apr 9
Toward the synthesis of pyroglutamate lauroyl ester: biocatalysis versus chemical catalysis.
2004 Feb
Stabilization of peptide guinea pig myelin basic protein 72-85 by N-terminal acetylation-implications for immunological studies.
2004 Feb
Expression, purification, and characterization of avian Thy-1 from Lec1 mammalian and Tn5 insect cells.
2004 Feb
Human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site.
2004 Feb 10
Identification of endogenous phosphorylation sites of bovine medium and low molecular weight neurofilament proteins by tandem mass spectrometry.
2004 Feb 24
Synthesis of (2S,3S)-3'-fluoroisoleucine.
2004 Mar 7
Alpha-tocopherol pro-vitamins: synthesis, hydrolysis and accumulation in rabbit ear skin.
2004 Oct 19
Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions.
2004 Sep
Formation of extracellular glutamate from glutamine: exclusion of pyroglutamate as an intermediate.
2005 Aug 2
The removal of pyroglutamic acid from monoclonal antibodies without denaturation of the protein chains.
2005 Jul 1
Synthesis of 1,3-dioxo-hexahydropyrido[1,2-c][1,3]diazepine carboxylates, a new bicyclic skeleton formed by ring expansion-RCM methodology.
2005 Sep 21
Thermostability and in vitro digestibility of a purified major allergen 2S albumin (Ses i 1) from white sesame seeds (Sesamum indicum L.).
2005 Sep 25
CFSUM1 and CFSUM2 in urine from patients with chronic fatigue syndrome are methodological artefacts.
2006 Feb
Patents

Sample Use Guides

In Vivo Use Guide
Sources: Topical, as a compontent of lotions, creams and other cosmetic products.
Topical, as a compontent of lotions, creams and other cosmetic products.
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 16 20:35:36 UTC 2022
Edited
by admin
on Fri Dec 16 20:35:36 UTC 2022
Record UNII
V5PC588N7G
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MAGNESIUM PIDOLATE
EP   MART.   WHO-DD  
Common Name English
MAGNESIUM PIDOLATE [MART.]
Common Name English
Magnesium pidolate [WHO-DD]
Common Name English
MAGNESIUM PCA
INCI  
INCI  
Official Name English
PIDOLIC ACID MAGNESIUM SALT (2:1)
Common Name English
MAGNESIUM PCA [INCI]
Common Name English
L-PROLINE, 5-OXO-, MAGNESIUM SALT (2:1)
Common Name English
MAGNESIUM PIDOLATE [EP MONOGRAPH]
Common Name English
MAGNESIUM PYROGLUTAMATE
Common Name English
Classification Tree Code System Code
WHO-VATC QA12CC08
Created by admin on Fri Dec 16 20:35:36 UTC 2022 , Edited by admin on Fri Dec 16 20:35:36 UTC 2022
WHO-ATC A12CC08
Created by admin on Fri Dec 16 20:35:36 UTC 2022 , Edited by admin on Fri Dec 16 20:35:36 UTC 2022
Code System Code Type Description
WIKIPEDIA
MAGNESIUM PIDOLATE
Created by admin on Fri Dec 16 20:35:36 UTC 2022 , Edited by admin on Fri Dec 16 20:35:36 UTC 2022
PRIMARY
DRUG BANK
DBSALT002689
Created by admin on Fri Dec 16 20:35:36 UTC 2022 , Edited by admin on Fri Dec 16 20:35:36 UTC 2022
PRIMARY
ChEMBL
CHEMBL397976
Created by admin on Fri Dec 16 20:35:36 UTC 2022 , Edited by admin on Fri Dec 16 20:35:36 UTC 2022
PRIMARY
FDA UNII
V5PC588N7G
Created by admin on Fri Dec 16 20:35:36 UTC 2022 , Edited by admin on Fri Dec 16 20:35:36 UTC 2022
PRIMARY
DAILYMED
V5PC588N7G
Created by admin on Fri Dec 16 20:35:36 UTC 2022 , Edited by admin on Fri Dec 16 20:35:36 UTC 2022
PRIMARY
PUBCHEM
14559042
Created by admin on Fri Dec 16 20:35:36 UTC 2022 , Edited by admin on Fri Dec 16 20:35:36 UTC 2022
PRIMARY
RXCUI
116240
Created by admin on Fri Dec 16 20:35:36 UTC 2022 , Edited by admin on Fri Dec 16 20:35:36 UTC 2022
PRIMARY RxNorm
DRUG CENTRAL
4597
Created by admin on Fri Dec 16 20:35:36 UTC 2022 , Edited by admin on Fri Dec 16 20:35:36 UTC 2022
PRIMARY
ECHA (EC/EINECS)
263-365-7
Created by admin on Fri Dec 16 20:35:36 UTC 2022 , Edited by admin on Fri Dec 16 20:35:36 UTC 2022
PRIMARY
EVMPD
SUB03045MIG
Created by admin on Fri Dec 16 20:35:36 UTC 2022 , Edited by admin on Fri Dec 16 20:35:36 UTC 2022
PRIMARY
CAS
62003-27-4
Created by admin on Fri Dec 16 20:35:36 UTC 2022 , Edited by admin on Fri Dec 16 20:35:36 UTC 2022
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY