LEUKOTRIENE A-4 HYDROLASE

Approval Year

Substance Class	Protein
Protein Type	ENZYME
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	V38765PUZ6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LEUKOTRIENE A-4 HYDROLASE

Common Name

English

LEUKOTRIENE A4 HYDROLASE

Preferred Name

English

LTA4H

Common Name

English

LTA-4 HYDROLASE

Common Name

English

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Code System

Code

Type

Description

FDA UNII

V38765PUZ6

PRIMARY

UNIPROT

P09960

PRIMARY

Showing 1 to 2 of 2 entries

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Subunit 0

Linkage Type	Residue Index
COORDINATION COMPOUND	1_295	1_299	1_318

Related Record Type Details


					T6WM2IY2LM

DG-051 FREE BASE

INHIBITOR -> TARGET

Qualification:

IC50

Amount:

47 NANOMOLAR (average)


					HF6P5EF2F6

CHR-79888

INHIBITOR -> TARGET

Amount:


					59CF90960T

LYS-006

INHIBITOR -> TARGET

Qualification:

IC50

Amount:

0.12 NANOMOLAR [0.11 to 0.13] (average)


					R5CDF0LNV3

JNJ-40929837

INHIBITOR -> TARGET


					J64RI4D29U

ACEBILUSTAT

INHIBITOR -> TARGET

Structural Modifications

Modification Type	Location Site	Location Type	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_72] [1_336] [1_413] [1_572]		N6-ACETYLLYSINE	470AD5VY1X
AMINO ACID SUBSTITUTION	[1_415]		DEXFOSFOSERINE	VI4F0K069V
AMINO_ACID_SUBSTITUTION	[1_295] [1_299] [1_318]	SITE_SPECIFIC	E1H2-TYPE ZINC FINGER	1GK53N83CJ

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL