Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C11H11IN2O |
| Molecular Weight | 314.1223 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1N(C(=O)C(I)=C1C)C2=CC=CC=C2
InChI
InChIKey=ZZOBLCHCPLOXCE-UHFFFAOYSA-N
InChI=1S/C11H11IN2O/c1-8-10(12)11(15)14(13(8)2)9-6-4-3-5-7-9/h3-7H,1-2H3
| Molecular Formula | C11H11IN2O |
| Molecular Weight | 314.1223 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/8091756
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/8091756
Iodoantipyrine belongs to the group of nonsteroid anti-inflammatory compounds. It has being shown to treat and prevent tick-borne encephalitis in mice. Iodoantipyrine has also be shown to be useful as a cerebral blood flow marker. ¹²³I-4-Iodoantipyrine (4-IAP) has been suggested as a radiopharmaceutical for direct imaging of regional cerebral perfusion.
Approval Year
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
27 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6531160/ |
18 MBq single, intravenous dose: 18 MBq route of administration: Intravenous experiment type: SINGLE co-administered: |
IODOANTIPYRINE plasma | Homo sapiens population: UNHEALTHY age: UNKNOWN sex: UNKNOWN food status: UNKNOWN |
|
9 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6531160/ |
18 MBq single, intravenous dose: 18 MBq route of administration: Intravenous experiment type: SINGLE co-administered: |
IODOANTIPYRINE plasma | Homo sapiens population: HEALTHY age: UNKNOWN sex: UNKNOWN food status: UNKNOWN |
Doses
| Dose | Population | Adverse events |
|---|---|---|
0.03 g 3 times / day multiple, oral Studied dose Dose: 0.03 g, 3 times / day Route: oral Route: multiple Dose: 0.03 g, 3 times / day Sources: |
unhealthy, 33 years |
Other AEs: Goitre... |
0.03 g 6 times / day multiple, oral Studied dose Dose: 0.03 g, 6 times / day Route: oral Route: multiple Dose: 0.03 g, 6 times / day Sources: |
unhealthy, 48 years |
Other AEs: Goitre... |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Goitre | 0.03 g 3 times / day multiple, oral Studied dose Dose: 0.03 g, 3 times / day Route: oral Route: multiple Dose: 0.03 g, 3 times / day Sources: |
unhealthy, 33 years |
|
| Goitre | 0.03 g 6 times / day multiple, oral Studied dose Dose: 0.03 g, 6 times / day Route: oral Route: multiple Dose: 0.03 g, 6 times / day Sources: |
unhealthy, 48 years |
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Use of interferon inducers for pharmacological correction of cytokine disturbances in patients with recurrent genital herpes]. | 2010-08 |
|
| [Use of the interferon inductor iodantipirine in the prevention and treatment of some viral infections]. | 2010-07-09 |
|
| Animal models and biomarkers of neuropathy in diabetic rodents. | 2010-06 |
|
| The effects of isoflurane pretreatment on cerebral blood flow, capillary permeability, and oxygen consumption in focal cerebral ischemia in rats. | 2010-05-01 |
|
| Mapping selective neuronal loss and microglial activation in the salvaged neocortical penumbra in the rat. | 2010-01-01 |
|
| Fenofibrate improves cerebral blood flow after middle cerebral artery occlusion in mice. | 2010-01 |
|
| Quantitative imaging of coronary blood flow. | 2010 |
|
| Effects of fentanyl pretreatment on regional cerebral blood flow in focal cerebral ischemia in rats. | 2010 |
|
| Increase in tumour permeability following TGF-beta type I receptor-inhibitor treatment observed by dynamic contrast-enhanced MRI. | 2009-12-01 |
|
| Why amphibians are more sensitive than mammals to xenobiotics. | 2009-11-04 |
|
| Sex differences in functional brain activation during noxious visceral stimulation in rats. | 2009-09 |
|
| Quantitative estimation of tissue blood flow rate. | 2009 |
|
| Changes in regional brain perfusion during functional brain activation: comparison of [(64)Cu]-PTSM with [(14)C]-Iodoantipyrine. | 2008-10-09 |
|
| Changes of cerebral blood flow during the secondary expansion of a cortical contusion assessed by 14C-iodoantipyrine autoradiography in mice using a non-invasive protocol. | 2008-07 |
|
| Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia. | 2008-07 |
|
| The effect of isovolemic hemodilution with oxycyte, a perfluorocarbon emulsion, on cerebral blood flow in rats. | 2008-04-23 |
|
| Flattened cortical maps of cerebral function in the rat: a region-of-interest approach to data sampling, analysis and display. | 2008-03-28 |
|
| A flow sensitive alternating inversion recovery (FAIR)-MRI protocol to measure hemispheric cerebral blood flow in a mouse stroke model. | 2008-03 |
|
| Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model. | 2008-02-08 |
|
| Reorganization of functional brain maps after exercise training: Importance of cerebellar-thalamic-cortical pathway. | 2007-12-12 |
|
| [Epileptogenic and non-epileptogenic zones: blood flow studies of temporo-limbic seizures]. | 2007-12 |
|
| Soluble epoxide hydrolase: a novel therapeutic target in stroke. | 2007-12 |
|
| Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients. | 2007-07 |
|
| Cortical contusion induces trans-hemispheric reorganization of blood flow maps. | 2007-04-13 |
|
| Persistent cerebrovascular effects of MDMA and acute responses to the drug. | 2006-07 |
|
| Multiple retinal hemorrhage following anterior chamber paracentesis in uveitic glaucoma. | 2006-06 |
|
| Optimal window for ictal blood flow mapping. Insight from the study of discrete temporo-limbic seizures in rats. | 2006-05 |
|
| Effects of estrogen on platelet reactivity after transient forebrain ischemia in rats. | 2005-10 |
|
| Time course and mapping of cerebral perfusion during amygdala secondarily generalized seizures. | 2005-08 |
|
| The endothelin B (ETB) receptor agonist IRL 1620 is highly vasoconstrictive in two syngeneic rat tumour lines: potential for selective tumour blood flow modification. | 2005-07-11 |
|
| Restoration of cerebral vasoreactivity by an L-type calcium channel blocker following fluid percussion brain injury. | 2005-07 |
|
| Role of nitric oxide in cerebral blood flow changes during kainate seizures in mice: genetic and pharmacological approaches. | 2005-03 |
|
| Relationship between flow-metabolism uncoupling and evolving axonal injury after experimental traumatic brain injury. | 2004-09 |
|
| Regional heterogeneity of cerebral blood flow response to graded pressure-controlled hemorrhage. | 2004-03 |
|
| Evolution of diaschisis in a focal stroke model. | 2004-03 |
|
| Extension of cerebral hypoperfusion and ischaemic pathology beyond MCA territory after intraluminal filament occlusion in C57Bl/6J mice. | 2004-01-30 |
|
| Activation of cerebral cortex during acoustic challenge or acute foot-shock in freely moving, nontethered rats. | 2004-01-02 |
|
| Effects of chronic isovolaemic haemodilution on regional cerebral blood flow in conscious rats. | 2004-01 |
|
| Inhibition of [18F]FP-TZTP binding by loading doses of muscarinic agonists P-TZTP or FP-TZTP in vivo is not due to agonist-induced reduction in cerebral blood flow. | 2003-11 |
|
| Functional brain mapping in freely moving rats during treadmill walking. | 2003-08 |
|
| Effects of tin-protoporphyrin IX on blood flow in a rat tumor model. | 2003-05 |
|
| Direct comparison of local cerebral blood flow rates measured by MRI arterial spin-tagging and quantitative autoradiography in a rat model of experimental cerebral ischemia. | 2003-02 |
|
| Cerebral hypoperfusion and delayed hippocampal response after induction of adult kaolin hydrocephalus. | 2003-01 |
|
| Cortical spreading depression causes a long-lasting decrease in cerebral blood flow and induces tolerance to permanent focal ischemia in rat brain. | 2003-01 |
|
| Progesterone administration during reperfusion, but not preischemia alone, reduces injury in ovariectomized rats. | 2002-10 |
|
| Dynamic variations of local cerebral blood flow in maximal electroshock seizures in the rat. | 2002-10 |
|
| Early effects of acid-base management during hypothermia on cerebral infarct volume, edema, and cerebral blood flow in acute focal cerebral ischemia in rats. | 2002-10 |
|
| The vascular response of tumor and normal tissues in the rat to the vascular targeting agent, combretastatin A-4-phosphate, at clinically relevant doses. | 2002-10 |
|
| Effect of mild hypothermia on energy state recovery following transient forebrain ischemia in the gerbil. | 2002-07 |
|
| Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack. | 2002-06 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:30:38 GMT 2025
by
admin
on
Mon Mar 31 18:30:38 GMT 2025
|
| Record UNII |
V30V6H1QX4
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C257
Created by
admin on Mon Mar 31 18:30:38 GMT 2025 , Edited by admin on Mon Mar 31 18:30:38 GMT 2025
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
100000077380
Created by
admin on Mon Mar 31 18:30:38 GMT 2025 , Edited by admin on Mon Mar 31 18:30:38 GMT 2025
|
PRIMARY | |||
|
129-81-7
Created by
admin on Mon Mar 31 18:30:38 GMT 2025 , Edited by admin on Mon Mar 31 18:30:38 GMT 2025
|
PRIMARY | |||
|
C008135
Created by
admin on Mon Mar 31 18:30:38 GMT 2025 , Edited by admin on Mon Mar 31 18:30:38 GMT 2025
|
PRIMARY | |||
|
SUB14251MIG
Created by
admin on Mon Mar 31 18:30:38 GMT 2025 , Edited by admin on Mon Mar 31 18:30:38 GMT 2025
|
PRIMARY | |||
|
DTXSID7046047
Created by
admin on Mon Mar 31 18:30:38 GMT 2025 , Edited by admin on Mon Mar 31 18:30:38 GMT 2025
|
PRIMARY | |||
|
V30V6H1QX4
Created by
admin on Mon Mar 31 18:30:38 GMT 2025 , Edited by admin on Mon Mar 31 18:30:38 GMT 2025
|
PRIMARY | |||
|
C77360
Created by
admin on Mon Mar 31 18:30:38 GMT 2025 , Edited by admin on Mon Mar 31 18:30:38 GMT 2025
|
PRIMARY | |||
|
8522
Created by
admin on Mon Mar 31 18:30:38 GMT 2025 , Edited by admin on Mon Mar 31 18:30:38 GMT 2025
|
PRIMARY | |||
|
204-966-6
Created by
admin on Mon Mar 31 18:30:38 GMT 2025 , Edited by admin on Mon Mar 31 18:30:38 GMT 2025
|
PRIMARY |