AGN-194310

CCC1=CC=C(C=C1)C2=CC(C)(C)SC3=CC=C(C=C23)C#CC4=CC=C(C=C4)C(O)=O

InChIKey=LHUPKWKWYWOMSK-UHFFFAOYSA-N

InChI=1S/C28H24O2S/c1-4-19-7-12-22(13-8-19)25-18-28(2,3)31-26-16-11-21(17-24(25)26)6-5-20-9-14-23(15-10-20)27(29)30/h7-18H,4H2,1-3H3,(H,29,30)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
Retinoic acid receptor beta 18 Target ID: CHEMBL2008 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10465407	Agonist 2752	2.0 nM [Kd]
Retinoic acid receptor alpha 11 Target ID: CHEMBL2055 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10465407	Agonist 2752	3.0 nM [Kd]
Retinoic acid receptor gamma 18 Target ID: CHEMBL2003 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10465407	Agonist 2752	5.0 nM [Kd]

PubMed

Title	Date	PubMed
N-(4-hydroxyphenyl)retinamide induces apoptosis in human retinal pigment epithelial cells: retinoic acid receptors regulate apoptosis, reactive oxygen species generation, and the expression of heme oxygenase-1 and Gadd153.	2006-12	16972258
Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways.	2006-02-01	16178010

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:09:32 GMT 2025` Edited by `admin` on `Mon Mar 31 18:09:32 GMT 2025`
Record UNII	V2W3I5K9O0
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

AGN-194310

Common Name

English

4-(2-(4-(4-ETHYLPHENYL)-2,2-DIMETHYL-2H-1-BENZOTHIOPYRAN-6-YL)ETHYNYL)BENZOIC ACID

Preferred Name

English

BENZOIC ACID, 4-(2-(4-(4-ETHYLPHENYL)-2,2-DIMETHYL-2H-1-BENZOTHIOPYRAN-6-YL)ETHYNYL)-

Systematic Name

English

Code System Code Type Description

CAS

229961-45-9

Created by admin on Mon Mar 31 18:09:32 GMT 2025 , Edited by admin on Mon Mar 31 18:09:32 GMT 2025

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FDA UNII

V2W3I5K9O0

Created by admin on Mon Mar 31 18:09:32 GMT 2025 , Edited by admin on Mon Mar 31 18:09:32 GMT 2025

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PUBCHEM

9867046

Created by admin on Mon Mar 31 18:09:32 GMT 2025 , Edited by admin on Mon Mar 31 18:09:32 GMT 2025

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