XANTOFYL PALMITATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C72H116O4
Molecular Weight	1045.689
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	9
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCCCCCCCCC(=O)O[C@@H]1CC(C)=C(\C=C\C(C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(C)\C=C\[C@H]2C(C)=C[C@@H](CC2(C)C)OC(=O)CCCCCCCCCCCCCCC)C(C)(C)C1

InChI

InChIKey=YHGJHDJZIOYZIR-URPSFYETSA-N

InChI=1S/C72H116O4/c1-13-15-17-19-21-23-25-27-29-31-33-35-37-49-69(73)75-65-55-63(7)67(71(9,10)57-65)53-51-61(5)47-41-45-59(3)43-39-40-44-60(4)46-42-48-62(6)52-54-68-64(8)56-66(58-72(68,11)12)76-70(74)50-38-36-34-32-30-28-26-24-22-20-18-16-14-2/h39-48,51-55,65-67H,13-38,49-50,56-58H2,1-12H3/b40-39+,45-41+,46-42+,53-51+,54-52+,59-43+,60-44+,61-47+,62-48+/t65-,66+,67-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C72H116O4
Molecular Weight	1045.689
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	9
Optical Activity	UNSPECIFIED

Description
Sources: http://www.rad-ar.or.jp/siori/english/kekka_plain.cgi?n=36421
Curator's Comment: Description was created based on several sources, including https://www.mimaki-family-japan.com/item/detail?item_prefix=TF&item_code=001234&item_branch=001

Xantofyl palmitate (brand name Adaptinol) is an approved drug for retinitis pigmentosa in Japan since August 1956. Adaptinol promotes aerobic metabolism of the retina to expand visual field or delay the development of narrowing of visual field. It also acts on the retina to improve vision in the dark. It is usually used to transiently improve visual field and dark adaptation in patients with retinitis pigmentosa.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Retinitis pigmentosa 10 Sources: https://www.mimaki-family-japan.com/item/detail?item_prefix=TF&item_code=001234&item_branch=001	Primary		Approved 8429	Adaptinol Approved Use This medicine promotes aerobic metabolism of the retina to expand visual field or delay the development of narrowing of visual field. It also acts on the retina to help you see in the dark. It is usually used to transiently improve visual field and dark adaptation in patients with retinitis pigmentosa. Launch Date 1956

PubMed

Title	Date	PubMed
[Effect of heleniene (adaptinol) on sensitivity to light in man; experimental research].	1956 May	13340534
[Experiments on the effect of helenien on normal and reduced dark-adaptation].	1957	13520523
[The effects of helenien and vitamin A on the primary sight process. II. Tissue respiration of the isolated retina under the influence of helenien and vitamin A].	1959 Oct	14443136
[Effects of cyaninoside chloride and Heleniene on mesopic and scotopic vision in myopia and night blindness].	1984	6381579
Topical isopropyl unoprostone for retinitis pigmentosa: microperimetric results of the phase 2 clinical study.	2012 Dec	25135585

Patents

Sample Use Guides

In Vivo Use Guide

In general, for adults, take 1 tablet (5 mg of the active ingredient) at a time, 2 to 4 times a day.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:42:18 GMT 2023` Edited by `admin` on `Fri Dec 15 15:42:18 GMT 2023`
Record UNII	V2W1791D7V
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

XANTOFYL PALMITATE

Official Name

English

HELENIEN

Common Name

English

XANTOFYL PALMITATE [MART.]

Common Name

English

ADAPTINOL

Brand Name

English

DIPALMITOYLLUTEIN

Common Name

English

XANTHOPHYLL DIPALMITATE

Common Name

English

LUTEIN BISPALMITATE

Common Name

English

XANTHOPHYLL, DIPALMITATE

Common Name

English

LUTEIN DIPALMITATE

Common Name

English

Xantofyl palmitate [WHO-DD]

Common Name

English

xantofyl palmitate [INN]

Common Name

English

.BETA.,.EPSILON.-CAROTENE-3,3'-DIOL, 3,3'-DIHEXADECANOATE, (3R,3'R,6'R)-

Systematic Name

English

HELENIEN [JAN]

Common Name

English

.BETA.,.EPSILON.-CAROTENE-3,3'-DIOL, DIHEXADECANOATE, (3R,3'R,6'R)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C860