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Details

Stereochemistry ABSOLUTE
Molecular Formula C72H116O4
Molecular Weight 1045.689
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 9
Charge 0

SHOW SMILES / InChI
Structure of XANTOFYL PALMITATE

SMILES

CCCCCCCCCCCCCCCC(=O)O[C@@H]1CC(C)=C(\C=C\C(C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(C)\C=C\[C@H]2C(C)=C[C@@H](CC2(C)C)OC(=O)CCCCCCCCCCCCCCC)C(C)(C)C1

InChI

InChIKey=YHGJHDJZIOYZIR-URPSFYETSA-N
InChI=1S/C72H116O4/c1-13-15-17-19-21-23-25-27-29-31-33-35-37-49-69(73)75-65-55-63(7)67(71(9,10)57-65)53-51-61(5)47-41-45-59(3)43-39-40-44-60(4)46-42-48-62(6)52-54-68-64(8)56-66(58-72(68,11)12)76-70(74)50-38-36-34-32-30-28-26-24-22-20-18-16-14-2/h39-48,51-55,65-67H,13-38,49-50,56-58H2,1-12H3/b40-39+,45-41+,46-42+,53-51+,54-52+,59-43+,60-44+,61-47+,62-48+/t65-,66+,67-/m0/s1

HIDE SMILES / InChI
Molecular Formula C72H116O4
Molecular Weight 1045.689
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 3 / 3
E/Z Centers 9
Optical Activity UNSPECIFIED

Description
Curator's Comment: Description was created based on several sources, including https://www.mimaki-family-japan.com/item/detail?item_prefix=TF&item_code=001234&item_branch=001

Xantofyl palmitate (brand name Adaptinol) is an approved drug for retinitis pigmentosa in Japan since August 1956. Adaptinol promotes aerobic metabolism of the retina to expand visual field or delay the development of narrowing of visual field. It also acts on the retina to improve vision in the dark. It is usually used to transiently improve visual field and dark adaptation in patients with retinitis pigmentosa.

Originator

Bayer Yakuhin
1
Curator's Comment: # Bayer Yakuhin, Japan

Approval Year

Unknown
149124
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8583
Adaptinol

Approved Use

This medicine promotes aerobic metabolism of the retina to expand visual field or delay the development of narrowing of visual field. It also acts on the retina to help you see in the dark. It is usually used to transiently improve visual field and dark adaptation in patients with retinitis pigmentosa.

Launch Date

1956
PubMed

PubMed

TitleDatePubMed
Topical isopropyl unoprostone for retinitis pigmentosa: microperimetric results of the phase 2 clinical study.
2012-12
[Effects of cyaninoside chloride and Heleniene on mesopic and scotopic vision in myopia and night blindness].
1984
[The effects of helenien and vitamin A on the primary sight process. II. Tissue respiration of the isolated retina under the influence of helenien and vitamin A].
1959-10
[Experiments on the effect of helenien on normal and reduced dark-adaptation].
1957
[Effect of heleniene (adaptinol) on sensitivity to light in man; experimental research].
1956-05
Patents

Patents

US6191293
1

Sample Use Guides

In Vivo Use Guide
In general, for adults, take 1 tablet (5 mg of the active ingredient) at a time, 2 to 4 times a day.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:06:09 GMT 2025
Edited
by admin
on Mon Mar 31 18:06:09 GMT 2025
Record UNII
V2W1791D7V
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HELENIEN
JAN  
Preferred Name English
XANTOFYL PALMITATE
INN   MART.   WHO-DD  
INN  
Official Name English
XANTOFYL PALMITATE [MART.]
Common Name English
ADAPTINOL
Brand Name English
DIPALMITOYLLUTEIN
Common Name English
XANTHOPHYLL DIPALMITATE
Common Name English
LUTEIN BISPALMITATE
Common Name English
XANTHOPHYLL, DIPALMITATE
Common Name English
LUTEIN DIPALMITATE
Common Name English
Xantofyl palmitate [WHO-DD]
Common Name English
xantofyl palmitate [INN]
Common Name English
.BETA.,.EPSILON.-CAROTENE-3,3'-DIOL, 3,3'-DIHEXADECANOATE, (3R,3'R,6'R)-
Systematic Name English
HELENIEN [JAN]
Common Name English
.BETA.,.EPSILON.-CAROTENE-3,3'-DIOL, DIHEXADECANOATE, (3R,3'R,6'R)-
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C860
Created by admin on Mon Mar 31 18:06:09 GMT 2025 , Edited by admin on Mon Mar 31 18:06:09 GMT 2025
Code System Code Type Description
SMS_ID
100000079351
Created by admin on Mon Mar 31 18:06:09 GMT 2025 , Edited by admin on Mon Mar 31 18:06:09 GMT 2025
PRIMARY
MESH
C042447
Created by admin on Mon Mar 31 18:06:09 GMT 2025 , Edited by admin on Mon Mar 31 18:06:09 GMT 2025
PRIMARY
INN
1551
Created by admin on Mon Mar 31 18:06:09 GMT 2025 , Edited by admin on Mon Mar 31 18:06:09 GMT 2025
PRIMARY
FDA UNII
V2W1791D7V
Created by admin on Mon Mar 31 18:06:09 GMT 2025 , Edited by admin on Mon Mar 31 18:06:09 GMT 2025
PRIMARY
ChEMBL
CHEMBL2105817
Created by admin on Mon Mar 31 18:06:09 GMT 2025 , Edited by admin on Mon Mar 31 18:06:09 GMT 2025
PRIMARY
PUBCHEM
5281240
Created by admin on Mon Mar 31 18:06:09 GMT 2025 , Edited by admin on Mon Mar 31 18:06:09 GMT 2025
PRIMARY
ECHA (EC/EINECS)
208-916-4
Created by admin on Mon Mar 31 18:06:09 GMT 2025 , Edited by admin on Mon Mar 31 18:06:09 GMT 2025
PRIMARY
EPA CompTox
DTXSID101023901
Created by admin on Mon Mar 31 18:06:09 GMT 2025 , Edited by admin on Mon Mar 31 18:06:09 GMT 2025
PRIMARY
NCI_THESAURUS
C66661
Created by admin on Mon Mar 31 18:06:09 GMT 2025 , Edited by admin on Mon Mar 31 18:06:09 GMT 2025
PRIMARY
CAS
547-17-1
Created by admin on Mon Mar 31 18:06:09 GMT 2025 , Edited by admin on Mon Mar 31 18:06:09 GMT 2025
PRIMARY
EVMPD
SUB00098MIG
Created by admin on Mon Mar 31 18:06:09 GMT 2025 , Edited by admin on Mon Mar 31 18:06:09 GMT 2025
PRIMARY
Related Record Type Details
Structure of XANTOFYL PALMITATE
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