Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H34O5 |
| Molecular Weight | 354.481 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCC[C@@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O
InChI
InChIKey=GMVPRGQOIOIIMI-CHCORRSHSA-N
InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16-,17-,19-/m1/s1
| Molecular Formula | C20H34O5 |
| Molecular Weight | 354.481 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 1 |
| Optical Activity | UNSPECIFIED |
15-Epiprostaglandin E1 is a synthetic prostaglandin analogue. The activity of the racemic synthetic prostaglandin is approximately one-half that of the naturally occurring compound. 15-Epiprostaglandin E1 is 4% and 6% as potent as PGE1 in contracting the rat uterus and guinea pig ileum. PGA1 is very potent vasodilator and hypotensive agent, whereas its epimer 15-Epiprostaglandin E1 has a little vasodilator or hypotensive effects in anaesthetized dogs. 15-Epiprostaglandin E1 is a non-competitive inhibitor of 15-hydroxyprostaglandin dehydrogenase from human placenta.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Biological activity of synthetic prostaglandins. | 1969 Mar 29 |
|
| Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. | 1976 Nov |
|
| Conformational analysis of prastaglandins. III. Study on active sites and conformation-action relationship. | 1977 Dec |
|
| Quantitative determination of alprostadil (PGE) in bulk drug and pharmaceutical formulations by high-performance liquid chromatography. | 1984 Jan 20 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 07:55:07 UTC 2023
by
admin
on
Sat Dec 16 07:55:07 UTC 2023
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| Record UNII |
V2N896SN9V
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| Record Status |
Validated (UNII)
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5283056
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20897-91-0
Created by
admin on Sat Dec 16 07:55:07 UTC 2023 , Edited by admin on Sat Dec 16 07:55:07 UTC 2023
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V2N896SN9V
Created by
admin on Sat Dec 16 07:55:07 UTC 2023 , Edited by admin on Sat Dec 16 07:55:07 UTC 2023
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| Related Record | Type | Details | ||
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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