Ixotatug Vedotin

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 13:12:49 GMT 2025` Edited by `admin` on `Wed Apr 02 13:12:49 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	V2JQK5RVM3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Ixotatug Vedotin

Official Name

English

H-gamma1 heavy chain (1-447) [VH Musmus/Homsap (Mus musculus IGHV6-3*01 (88.8%) -(IGHD) -IGHJ2*01 (90.9%) T123>L (112)/Homo sapiens IGHV3-23*03 (82.7%) -(IGHD) -IGHJ5*01 (91.7%) V124>L (113), CDR-IMGT [8.10.8] (26-33.51-60.99-106)) (1-117) -Homo sapiens

Preferred Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens CLDN6 (claudin 6, claudin-6)], monoclonal antibody, conjugated on an average of four cysteinyl residues to vedotin, comprising a cleavable linker and monomethylauristatin E (MMAE) (ixotatug vedotin)

Common Name

English

Immunoglobulin G1, anti-(human claudin 6) (human monoclonal TORL-1-23 ?1-chain), disulfide with human monoclonal TORL-1-23 ?-chain, dimer, reduced, tetrakis(thioether) with N-[[[4-[[N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl]-L-valyl-N5-(amino

Common Name

English

ixotatug vedotin [INN]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

935723

Created by admin on Wed Apr 02 13:12:49 GMT 2025 , Edited by admin on Wed Apr 02 13:12:49 GMT 2025

Code System Code Type Description

FDA UNII

V2JQK5RVM3

Created by admin on Wed Apr 02 13:12:49 GMT 2025 , Edited by admin on Wed Apr 02 13:12:49 GMT 2025

PRIMARY

INN

13517

Created by admin on Wed Apr 02 13:12:49 GMT 2025 , Edited by admin on Wed Apr 02 13:12:49 GMT 2025

PRIMARY

CAS

3018937-00-0

Created by admin on Wed Apr 02 13:12:49 GMT 2025 , Edited by admin on Wed Apr 02 13:12:49 GMT 2025

PRIMARY

From	To
1_22	1_98
2_22	2_98
2_144	2_200
2_220	4_214
2_261	2_321
1_144	1_200
2_367	2_425
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_220	3_214
1_226	2_226
1_229	2_229
1_261	1_321
1_367	1_425

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_297
N	2_297

Related Record Type Details


					D64CJ98P8W

Ixotatug

PARENT -> CONJUGATE

Amount:


					MRC5FX426I

CLAUDIN-6

TARGET->CONJUGATED TOXIN

Amount:

Related Record Type Details


					V2JQK5RVM3

Ixotatug Vedotin

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION		RESIDUE_SPECIFIC	C	Amount:	Cysteinyl vedotin	6603L01WUR
AMINO ACID REMOVAL	[1_447] [2_447]	C-TERMINUS	K	Amount:	LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER AVERAGE	CHEMICAL