Details
Stereochemistry | ACHIRAL |
Molecular Formula | C12H30N2.2C6H5O3S |
Molecular Weight | 516.714 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[O-]S(=O)(=O)C1=CC=CC=C1.[O-]S(=O)(=O)C2=CC=CC=C2.C[N+](C)(C)CCCCCC[N+](C)(C)C
InChI
InChIKey=KQHXGIXCFWNHSW-UHFFFAOYSA-L
InChI=1S/C12H30N2.2C6H6O3S/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;2*7-10(8,9)6-4-2-1-3-5-6/h7-12H2,1-6H3;2*1-5H,(H,7,8,9)/q+2;;/p-2
Molecular Formula | C12H30N2 |
Molecular Weight | 202.38 |
Charge | 2 |
Count |
|
Stereochemistry | MIXED |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C6H5O3S |
Molecular Weight | 157.167 |
Charge | -1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Hexamethonium is a nicotinic cholinergic antagonist. It was used to treat hypertension, but has never been approved and was discontinued because of the non-specified treatment. When this drug tried to use in medical study via inhalation, one of the volunteer died, the death has been described as “particularly disturbing ”because it was a healthy volunteer who had no thing to gain by taking part in the study. This volunteer participated in a study designed to provoke a mild asthma attack in order to help doctors discover the reflex that protects the lungs of healthy people against asthma attacks. Hexamethonium is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. Now it is widely used a research tool.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Nicotinic acetylcholine receptors Sources: https://www.ncbi.nlm.nih.gov/mesh/68018738 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved Usehypertensive crisis; acute ventricular failure in arterial hypertension; controlled hypotension. |
Doses
Dose | Population | Adverse events |
---|---|---|
500 mg 1 times / day steady, oral Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, adult n = 18 Health Status: unhealthy Condition: hypertension Age Group: adult Sex: unknown Population Size: 18 Sources: |
Other AEs: Hypotension, Constipation... Other AEs: Hypotension (18 patients) Sources: Constipation (18 patients) |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Constipation | 18 patients | 500 mg 1 times / day steady, oral Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, adult n = 18 Health Status: unhealthy Condition: hypertension Age Group: adult Sex: unknown Population Size: 18 Sources: |
Hypotension | 18 patients | 500 mg 1 times / day steady, oral Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, adult n = 18 Health Status: unhealthy Condition: hypertension Age Group: adult Sex: unknown Population Size: 18 Sources: |
Sample Use Guides
In Vivo Use Guide
Sources: https://profiles.nlm.nih.gov/ps/access/XFBBJR.pdf
intravenous: 5 to 50 mg;
ora: 0.5 mg
subcutaneous: 10-100 mg
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2819331
The action of hexamethonium has been studied at a range of muscarinic receptors in vitro by use of both functional and radioligand binding studies. In functional studies, hexamethonium exhibited little or no significant (P less than 0.05) antagonism of contractile responses to carbachol at muscarinic receptors in the guinea-pig ileum, oesophageal muscularis mucosae, urinary bladder and trachea. However, antagonism was observed at muscarinic receptors in the guinea-pig left atria mediating negative inotropic responses and the calculated pKB value was 3.80. Hexamethonium also antagonized contractile responses to carbachol in the canine saphenous vein. The pKB value at these receptors was 3.75. 3. In the presence of 3.2 mM hexamethonium, the pA2 value for methoctramine at atrial muscarinic receptors was reduced by approximately 10 fold (control pA2 value was 7.81 +/- 0.05; pA2 value in hexamethonium was 6.73 +/- 0.04).
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:51:51 GMT 2023
by
admin
on
Sat Dec 16 09:51:51 GMT 2023
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Record UNII |
V26UVZ0360
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Record Status |
Validated (UNII)
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Record Version |
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-
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13776
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100000127620
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SUB33677
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DTXSID60242702
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971-60-8
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Benzohexonium
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V26UVZ0360
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admin on Sat Dec 16 09:51:51 GMT 2023 , Edited by admin on Sat Dec 16 09:51:51 GMT 2023
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