FAZIRSIRAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 14:33:35 GMT 2023` Edited by `admin` on `Sat Dec 16 14:33:35 GMT 2023`
Nucleic Acid Type	RNAI
Nucleic Acid Subtype
Sequence Origin	SYNTHETIC
Sequence Type	COMPLETE
Record UNII	V20IVC0OGQ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FAZIRSIRAN

Official Name

English

ADS-001 FREE ACID

Code

English

RNA, ((1'-DE(6-AMINO-9H-PURIN-9-YL))DA-(5'->5')-SP-AM-GM-CM-GM-UM-UM- UM-AM-(2'-DEOXY-2'-FLUORO)G-(2'-DEOXY-2'-FLUORO)G-(2'-DEOXY-2'-FLUORO)C-AM- UM-GM-UM-UM-UM-AM-AM-CM-AM-(3'->3')-SP-(1'-DE(6-AMINO-9H-PURIN-9- YL))DA), 3'-(O-(CIS-4-((3S,8S)-17-((2-(ACE

Common Name

English

fazirsiran [INN]

Common Name

English

FAZIRSIRAN [USAN]

Common Name

English

Code System Code Type Description

USAN

HI-134

Created by admin on Sat Dec 16 14:33:35 GMT 2023 , Edited by admin on Sat Dec 16 14:33:35 GMT 2023

PRIMARY

FDA UNII

V20IVC0OGQ

Created by admin on Sat Dec 16 14:33:35 GMT 2023 , Edited by admin on Sat Dec 16 14:33:35 GMT 2023

PRIMARY

INN

11949

Created by admin on Sat Dec 16 14:33:35 GMT 2023 , Edited by admin on Sat Dec 16 14:33:35 GMT 2023

PRIMARY

CAS

2175009-08-0

Created by admin on Sat Dec 16 14:33:35 GMT 2023 , Edited by admin on Sat Dec 16 14:33:35 GMT 2023

PRIMARY

NCI_THESAURUS

C188640

Created by admin on Sat Dec 16 14:33:35 GMT 2023 , Edited by admin on Sat Dec 16 14:33:35 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_1-1_9;1_13-1_21;2_1;2_3;2_5;2_7-2_11;2_13;2_15;2_17;2_19;2_21	31 / 42
2'-Fluoro-Ribose	1_10-1_12;2_2;2_4;2_6;2_12;2_14;2_16;2_18;2_20	11 / 42

Linkage	Site Range	Site Count
Phosporothioate	2_2-2_3;2_21	3 / 40
Phosphate	1_2-1_21;2_4-2_20	37 / 40

Related Record Type Details


					V20IVC0OGQ

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS			UNSPECIFIED SUBSTANCE	d2a92a76 (not in database)
NUCLEOTIDE SUBSTITUTION	[1_21]	3'-TERMINUS			UNSPECIFIED SUBSTANCE	b3d71799 (not in database)