U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 18:22:10 GMT 2023
Edited
by admin
on Sat Dec 16 18:22:10 GMT 2023
Source Materials Class ORGANISM
Source Materials Type RECOMBINANT VIRUS
Organism Family Parvoviridae
Organism Genus Dependovirus
Organism Species adeno-associated virus
Author NONE
Infraspecific Type SUBSTRAIN
Infraspecific Name AAV8-RPGR
Part WHOLE
Record UNII
V1R4T1S1M0
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
COTORETIGENE TOLIPARVOVEC
INN   USAN  
Official Name English
RECOMBINANT SEROTYPE 8 ADENO-ASSOCIATED VIRAL VECTOR (AAV8) ENCODING A CODON OPTIMISED (CO) COPY OF THE CDNA ENCODING HUMAN RETINITIS PIGMENTOSA GTPASE REGULATOR (CORPGR)
Common Name English
AAV8-RPGR
Common Name English
A RECOMBINANT REPLICATION-DEFECTIVE ADENO-ASSOCIATED VIRAL VECTOR SEROTYPE 8 (RAAV8) ENCODING CODON-OPTIMISED HUMAN RETINITIS PIGMENTOSA GTPASE REGULATOR (RPGR), UNDER THE CONTROL OF HUMAN RHODOPSIN KINASE (RK) PROMOTER AND BOVINE GROWTH HORMONE POLY(A)
Common Name English
cotoretigene toliparvovec [INN]
Common Name English
COTORETIGENE TOLIPARVOVEC [USAN]
Common Name English
Code System Code Type Description
INN
11358
Created by admin on Sat Dec 16 18:22:10 GMT 2023 , Edited by admin on Sat Dec 16 18:22:10 GMT 2023
PRIMARY
FDA UNII
V1R4T1S1M0
Created by admin on Sat Dec 16 18:22:10 GMT 2023 , Edited by admin on Sat Dec 16 18:22:10 GMT 2023
PRIMARY
CAS
2246424-95-1
Created by admin on Sat Dec 16 18:22:10 GMT 2023 , Edited by admin on Sat Dec 16 18:22:10 GMT 2023
PRIMARY
NCI_THESAURUS
C177095
Created by admin on Sat Dec 16 18:22:10 GMT 2023 , Edited by admin on Sat Dec 16 18:22:10 GMT 2023
PRIMARY
USAN
GH-110
Created by admin on Sat Dec 16 18:22:10 GMT 2023 , Edited by admin on Sat Dec 16 18:22:10 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN X-LINKED RETINITIS PIGMENTOSA GTPASE REGULATOR ORF15 L0031JC5I7
INSERTED GENE EXPRESSION VECTOR COTORETIGENE TOLIPARVOVEC TRANSGENE INSERT VEC94OC288