THIANTOIN

US Previously Marketed

First approved in 1949

Details

Stereochemistry	RACEMIC
Molecular Formula	C13H10N2O2S
Molecular Weight	258.296
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C1NC(=O)C(N1)(C2=CC=CS2)C3=CC=CC=C3

InChI

InChIKey=DCPACFSINCUFEC-UHFFFAOYSA-N

InChI=1S/C13H10N2O2S/c16-11-13(15-12(17)14-11,10-7-4-8-18-10)9-5-2-1-3-6-9/h1-8H,(H2,14,15,16,17)

HIDE SMILES / InChI

Molecular Formula	C13H10N2O2S
Molecular Weight	258.296
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.drugfuture.com/chemdata/phethenylate-sodium.html | https://www.ncbi.nlm.nih.gov/pubmed/13151980

THIANTOIN (also known as phethenylate) is an anticonvulsant drug.

CNS Activity

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Epilepsy 121 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14938172	Preventing		Approved 8583	Thiantoin Approved Use Unknown

Doses

Dose	Population	Adverse events
120 mg 3 times / day steady, oral Recommended Dose: 120 mg, 3 times / day Route: oral Route: steady Dose: 120 mg, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13005124/	unhealthy, 16 years Health Status: unhealthy Age Group: 16 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/13005124/	Disc. AE: Hepatic insufficiency... AEs leading to discontinuation/dose reduction: Hepatic insufficiency (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/13005124/

AEs

AE	Significance	Dose	Population
Hepatic insufficiency	1 patient Disc. AE	120 mg 3 times / day steady, oral Recommended Dose: 120 mg, 3 times / day Route: oral Route: steady Dose: 120 mg, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13005124/	unhealthy, 16 years Health Status: unhealthy Age Group: 16 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/13005124/

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1L1LEK
ABI Chem	AC1Q6G57
Chemieliva Pharmaceutical Co., Ltd	PBCM0829873
eMolecules	260949449
NovoSeek	31325
ZINC	ZINC000005934359	http://zinc15.docking.org/substances/ZINC000005934359
ZINC	ZINC000005934489	http://zinc15.docking.org/substances/ZINC000005934489

PubMed

Title	Date	PubMed
Analgesic effects of clinically useful antiepileptics.	1954-04	13151980

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:18:52 GMT 2025` Edited by `admin` on `Mon Mar 31 21:18:52 GMT 2025`
Record UNII	V1989D4JPB
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

THIANTOIN

Common Name

English

NSC-400653

Preferred Name

English

2,4-IMIDAZOLIDINEDIONE, 5-PHENYL-5-(2-THIENYL)-

Systematic Name

English

THYPHENYTOIN

Common Name

English

HYDANTOIN, 5-PHENYL-5-(2-THIENYL)-

Systematic Name

English

THIANTOINE

Common Name

English

PHETHENYLATE

Common Name

English

Code System Code Type Description

CAS

7772-37-4