Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 2Na.AsHO4 |
| Molecular Weight | 184.909 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].O[74As]([O-])([O-])=O
InChI
InChIKey=IHZDYHDJAVUIBH-TWOSSSAOSA-L
InChI=1S/AsH3O4.2Na/c2-1(3,4)5;;/h(H3,2,3,4,5);;/q;2*+1/p-2/i1-1;;
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | AsHO4 |
| Molecular Weight | 138.9295 |
| Charge | -2 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Sodium arsenate as-74 (As74) has been the principal positron-emitting scanning agent. As74 as a commercial preparation for parenteral adminitration was made available towards the end of 1956. From March 1957 all studies were made with sodium arsenate rather than sodium arsenite. Sodium arsenate as-74 was used in the diagnosis of suvatentorial brain tumours. Traces of the element were found in all body tissues, and assays of injected As74 recovered in brain tumours showed highest values in meningiomas, followed, in order, by gliolastomas, metastatic carcinomas and astrocytomas.
Approval Year
Sample Use Guides
In Vivo Use Guide
Curator's Comment: Humans, brain tumor: An intravenous dose of 1.0 to 1.5 millicuries of sodium arsenate was given about 20 minutes before scanning. This dose was found to be optimum for the equipment. https://www.ncbi.nlm.nih.gov/pubmed/13871689
Rats: Arsenic in the form of sodium arsenate was used as a carrier and labeled with 74As. Various doses of arsenic were used (in the range 0.1-4.0 mg/kg) but in all cases the single dose had a volume of 0.3 cm3 and an activity of 1-2uCi (160,000-320,000 counts/min).
Route of Administration:
Intravenous
At low concentrations of extracellular As74-arsenate, such as 10(-6)M, uptake by the wild type strain 9790 of Streptococcus faecalis exhibited a single maximum at pH8; the mutant took up virtually no As74 at any pH. However, at the high concentration of 10(-4)M As74, the pH dependence of As74 uptake by the wild type became bimodal, with a maximum at about pH9 and a shoulder at about pH5.5.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:26:12 GMT 2023
by
admin
on
Fri Dec 15 15:26:12 GMT 2023
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| Record UNII |
UZA612G530
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C1937
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admin on Fri Dec 15 15:26:12 GMT 2023 , Edited by admin on Fri Dec 15 15:26:12 GMT 2023
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76958471
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UZA612G530
Created by
admin on Fri Dec 15 15:26:12 GMT 2023 , Edited by admin on Fri Dec 15 15:26:12 GMT 2023
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C152376
Created by
admin on Fri Dec 15 15:26:12 GMT 2023 , Edited by admin on Fri Dec 15 15:26:12 GMT 2023
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PRIMARY |