LADEMIRSEN SODIUM

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 14:04:41 GMT 2023` Edited by `admin` on `Sat Dec 16 14:04:41 GMT 2023`
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	UWG3VFQ5CQ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LADEMIRSEN SODIUM

Official Name

English

DNA, D(P-THIO)((2'-O-(2-METHOXYETHYL))RA-(2'-O,4'-C-((S)-ETHYLIDENE))RC-A-T-(2'-O,4'-C-((S)-ETHYLIDENE))RC-A-G-T-(2'-O,4'-C-((S)-ETHYLIDENE))RC-T-G-A-(2'-O,4'-C-((S)-ETHYLIDENE))RU-A-A-G-(2'-O,4'-C-((S)-ETHYLIDENE))RC-T-(2'-O-(2-METHOXYETHYL))RA), SODIUM

Systematic Name

English

RG-456070 SODIUM

Code

English

LADEMIRSEN SODIUM [USAN]

Common Name

English

RG-012 SODIUM

Code

English

DNA, D(P-THIO)((2'-O-(2-METHOXYETHYL))RA-(3'->4')-(2',5'-ANHYDRO-6'-DEOXY-4'-C-(HYDROXYMETHYL)-.ALPHA.-L-MANNOFURANO)C-A-T-(3'->4')-(2',5'-ANHYDRO-6'-DEOXY-4'-C-(HYDROXYMETHYL)-.ALPHA.-L-MANNOFURANO)C-A-G-T-(3'->4')-(2',5'-ANHYDRO-6'-DEOXY-4'-C-(HYDROXYM

Systematic Name

English

Code System Code Type Description

FDA UNII

UWG3VFQ5CQ

Created by admin on Sat Dec 16 14:04:41 GMT 2023 , Edited by admin on Sat Dec 16 14:04:41 GMT 2023

PRIMARY

CAS

1885122-05-3

Created by admin on Sat Dec 16 14:04:41 GMT 2023 , Edited by admin on Sat Dec 16 14:04:41 GMT 2023

PRIMARY

NCI_THESAURUS

C170088

Created by admin on Sat Dec 16 14:04:41 GMT 2023 , Edited by admin on Sat Dec 16 14:04:41 GMT 2023

PRIMARY

USAN

DE-173

Created by admin on Sat Dec 16 14:04:41 GMT 2023 , Edited by admin on Sat Dec 16 14:04:41 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methoxyethyl ribose	1_1;1_19	2 / 19
2'-O,4'-ethylene bridged Ribose	1_2;1_5;1_9;1_13;1_17	5 / 19
Deoxyribose (DNA)	1_3-1_4;1_6-1_8;1_10-1_12;1_14-1_16;1_18	12 / 19

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_2-1_19	18 / 18

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ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION	[1_2] [1_5] [1_9] [1_17]	2'-O,4'-C-((1S)-ETHANE-1,1-DIYL).BETA.-D-RIBOSE CYTIDINE	QZ18V6XE1B
NUCLEOSIDE_SUBSTITUTION	[1_13]	2'-O,4'-C-((1S)-ETHANE-1,1-DIYL).BETA.-D-RIBOSE URIDINE	TF497SHH7P
NUCLEOSIDE_SUBSTITUTION	[1_1] [1_19]	2'-O-(2-METHOXYETHYL)ADENOSINE	CPN45E0H91