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Details

Stereochemistry ACHIRAL
Molecular Formula C8H4O3
Molecular Weight 148.1156
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Phthalic anhydride

SMILES

O=C1OC(=O)C2=C1C=CC=C2

InChI

InChIKey=LGRFSURHDFAFJT-UHFFFAOYSA-N
InChI=1S/C8H4O3/c9-7-5-3-1-2-4-6(5)8(10)11-7/h1-4H

HIDE SMILES / InChI
Molecular Formula C8H4O3
Molecular Weight 148.1156
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
Identification of contact and respiratory sensitizers according to IL-4 receptor α expression and IL-2 production.
2012-04-15
An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G8.
2011-12
Detection of allergenic compounds using an IL-4/luciferase/CNS-1 transgenic mice model.
2011-04
Degradation of pentachlorophenol and 2,4-dichlorophenol by sequential visible-light driven photocatalysis and laccase catalysis.
2010-12-01
A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells.
2010-09
Removal of the endocrine disrupter butyl benzyl phthalate from the environment.
2010-06
A method for measuring mouse respiratory allergic reaction to low-dose chemical exposure to allergens: an environmental chemical of uncertain allergenicity, a typical contact allergen and a non-sensitizing irritant.
2010-05-19
Synthesis and antiviral activity of phthiobuzone analogues.
2010-02
Bis[2-(1,3-dioxoisoindolin-2-yl)eth-yl] phthalate.
2010-01-13
Optical and vibrational properties of 1,2-benzenedicarboxylic anhydride.
2009-09
Contact and respiratory sensitizers can be identified by cytokine profiles following inhalation exposure.
2009-07-10
Hydro-nium (3-oxo-1-phosphono-1,3-dihydro-isobenzofuran-1-yl)phospho-nate.
2009-01-10
Enhanced degradation and toxicity reduction of dihexyl phthalate by Fusarium oxysporum f. sp. pisi cutinase.
2007-01
Photocatalytic degradation of di(2-ethylhexyl)phthalate adsorbed by chitin A.
2007
Accelerated degradation of dipentyl phthalate by Fusarium oxysporum f. sp. pisi cutinase and toxicity evaluation of its degradation products using bioluminescent bacteria.
2006-05
Biodegradation of dipropyl phthalate and toxicity of its degradation products: a comparison of Fusarium oxysporum f. sp. pisi cutinase and Candida cylindracea esterase.
2005-10
Assessment of potency of allergenic activity of low molecular weight compounds based on IL-1alpha and IL-18 production by a murine and human keratinocyte cell line.
2005-06-01
Identifying airway sensitizers: cytokine mRNA profiles induced by various anhydrides.
2003-12-01
Degradation of an endocrine disrupting chemical, DEHP [di-(2-ethylhexyl)-phthalate], by Fusarium oxysporum f. sp. pisi cutinase.
2003-11
Phthalic anhydride allergy: development and characterization of optimized hapten-carrier conjugates for improved diagnosis.
2002-10
Assessment of preferential T-helper 1 or T-helper 2 induction by low molecular weight compounds using the local lymph node assay in conjunction with RT-PCR and ELISA for interferon-gamma and interleukin-4.
2000-01-15
The characteristics of specific IgG to phthalic anhydride (PA)-albumin conjugate.
1997-10
Induction of type I hypersensitivity in guinea pigs after inhalation of phthalic anhydride.
1994-10
Variable effects of chemical allergens on serum IgE concentration in mice. Preliminary evaluation of a novel approach to the identification of respiratory sensitizers.
1992-10
Divergent immune responses to respiratory and contact chemical allergens: antibody elicited by phthalic anhydride and oxazolone.
1992-02
Immunologic tests of specific antibodies to organic acid anhydrides.
1991-11
Immune responses of cynomolgus monkeys to phthalic anhydride.
1988-07
Establishing clinical and immunologic criteria for diagnosis of occupational immunologic lung disease with phthalic anhydride and tetrachlorophthalic anhydride exposures as a model.
1987-10
Specificity of the human IgE response to inhaled acid anhydrides.
1986-06
Detection of IgE-mediated respiratory sensitization in workers exposed to hexahydrophthalic anhydride.
1985-06
Clinical and immunologic evaluation of trimellitic anhydride-and phthalic anhydride-exposed workers using a questionnaire with comparative analysis of enzyme-linked immunosorbent and radioimmunoassay studies.
1982-03
Patents

Patents

JP1004252A
1
JP1034977A
1
JP1056719A
1
JP2000026414A
1
JP2000034404A
1
JP2000109557A
1
JP2000178195A
1
JP2000198852A
3
JP2001139770A
1
JP2002527515A
1
JP2003518131A
5
JP2004123572A
1
JP2006249441A
1
JP2007016175A
1
JP2007091629A
1
JP2009084366A
1
JP2012015519A
1
JP2642941B2
1
JP3131785B2
1
JP4276085B2
3
JP4802250B2
1
JPH00441572A
1
JPH00543713A
1
JPH00616903A
1
JPH01153656A
1
JPH02124950A
2
JPH02166111A
1
JPH02173056A
1
JPH0236217A
1
JPH0242057A
1
JPH0255757A
1
JPH029447A
1
JPH03208844A
3
JPH0335017A
1
JPH0357688A
1
JPH04108866A
1
JPH04144946A
1
JPH0415560A
1
JPH04236220A
1
JPH04296318A
1
JPH04300373A
1
JPH04312588A
1
JPH04320413A
1
JPH04352752A
3
JPH0485366A
1
JPH05156110A
1
JPH0532746A
1
JPH06145126A
1
JPH06157722A
1
JPH0616946A
1
JPH06172493A
1
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:12:05 GMT 2025
Edited
by admin
on Mon Mar 31 18:12:05 GMT 2025
Record UNII
UVL263I5BJ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NSC-10431
Preferred Name English
Phthalic anhydride
HSDB   MI  
Systematic Name English
1,3-ISOBENZOFURANDIONE
Systematic Name English
PHTHALIC ANHYDRIDE [MI]
Common Name English
1,2-BENZENEDICARBOXYLIC ANHYDRIDE
Systematic Name English
PHTHALIC ANHYDRIDE [HSDB]
Common Name English
Code System Code Type Description
CHEBI
36605
Created by admin on Mon Mar 31 18:12:05 GMT 2025 , Edited by admin on Mon Mar 31 18:12:05 GMT 2025
PRIMARY
CAS
85-44-9
Created by admin on Mon Mar 31 18:12:05 GMT 2025 , Edited by admin on Mon Mar 31 18:12:05 GMT 2025
PRIMARY
FDA UNII
UVL263I5BJ
Created by admin on Mon Mar 31 18:12:05 GMT 2025 , Edited by admin on Mon Mar 31 18:12:05 GMT 2025
PRIMARY
WIKIPEDIA
PHTHALIC ANHYDRIDE
Created by admin on Mon Mar 31 18:12:05 GMT 2025 , Edited by admin on Mon Mar 31 18:12:05 GMT 2025
PRIMARY
PUBCHEM
6811
Created by admin on Mon Mar 31 18:12:05 GMT 2025 , Edited by admin on Mon Mar 31 18:12:05 GMT 2025
PRIMARY
ECHA (EC/EINECS)
201-607-5
Created by admin on Mon Mar 31 18:12:05 GMT 2025 , Edited by admin on Mon Mar 31 18:12:05 GMT 2025
PRIMARY
NSC
10431
Created by admin on Mon Mar 31 18:12:05 GMT 2025 , Edited by admin on Mon Mar 31 18:12:05 GMT 2025
PRIMARY
HSDB
4012
Created by admin on Mon Mar 31 18:12:05 GMT 2025 , Edited by admin on Mon Mar 31 18:12:05 GMT 2025
PRIMARY
MERCK INDEX
m8754
Created by admin on Mon Mar 31 18:12:05 GMT 2025 , Edited by admin on Mon Mar 31 18:12:05 GMT 2025
PRIMARY Merck Index
EPA CompTox
DTXSID2021159
Created by admin on Mon Mar 31 18:12:05 GMT 2025 , Edited by admin on Mon Mar 31 18:12:05 GMT 2025
PRIMARY
MESH
C043103
Created by admin on Mon Mar 31 18:12:05 GMT 2025 , Edited by admin on Mon Mar 31 18:12:05 GMT 2025
PRIMARY
NIH
NCATS
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