Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C27H46O5 |
| Molecular Weight | 450.6511 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 13 / 13 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C[C@H](C)C(O)=O)[C@@]3(C)[C@@H](O)C[C@@H]2[C@@]4(C)CC[C@@H](O)C[C@@H]14
InChI
InChIKey=NPBCMXATLRCCLF-IRRLEISYSA-N
InChI=1S/C27H46O5/c1-6-17-20-12-16(28)9-10-26(20,4)21-13-22(29)27(5)18(14(2)11-15(3)25(31)32)7-8-19(27)23(21)24(17)30/h14-24,28-30H,6-13H2,1-5H3,(H,31,32)/t14-,15+,16-,17-,18-,19+,20+,21+,22+,23+,24-,26+,27-/m1/s1
| Molecular Formula | C27H46O5 |
| Molecular Weight | 450.6511 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 13 / 13 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
INT-777 is a semisynthetic bile acid that acts as an agonist of a transmembrane G protein-coupled receptor, TGR5. The novel roles of TGR5 in different diseases make it become a new drug target. It was shown, that INT-777 stimulated insulin secretion in pancreatic β-cells, reduced inflammation and inhibited atherosclerosis in mice.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells. | 2012-10-26 |
|
| The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling. | 2011-06 |
|
| Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. | 2009-12-24 |
Patents
Sample Use Guides
C57BL/6J mice: INT-777 admixed at a dose of 30 mg/kg/day (mkd) with the diet in an intervention study in C57BL/6J mice in which diabesity was induced by HF feeding for 14 weeks.
Route of Administration:
Oral
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:50:48 GMT 2025
by
admin
on
Mon Mar 31 21:50:48 GMT 2025
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| Record UNII |
UTD8BCW6B8
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| Record Status |
Validated (UNII)
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| Record Version |
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UTD8BCW6B8
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45483949
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admin on Mon Mar 31 21:50:48 GMT 2025 , Edited by admin on Mon Mar 31 21:50:48 GMT 2025
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