Thymoctonan (also known as Thymic humoral factor γ2 ) is an octapeptide thymic hormone patented by Yeda Research and Development Co. Ltd. as an immunoregulatory agent. In preclinical models, Thymoctonan exerts potent anti-tumor activity in mice and significantly increases the specific cytotoxic response of immune spleen cells. In addition, Thymoctonan treatment improved the competence of immune spleen cells in adoptive immunotherapy when performed in combination with chemotherapy by melphalan. Besides that Thymoctonan enhancing the anti-viral potential of murine cytomegalovirus immune spleen cells. In fatal murine cytomegalovirus infection model, daily injections of Thymoctonan- enhanced murine cytomegalovirus immune spleen cells prevented the development of a fatal disease in 93% of the recipient mice.
Approval Year
| Substance Class |
Protein
Created
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admin
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Edited
Wed Apr 02 11:58:34 GMT 2025
by
admin
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Wed Apr 02 11:58:34 GMT 2025
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| Protein Type | PEPTIDE |
| Protein Sub Type | |
| Sequence Origin | BOVINE |
| Sequence Type | COMPLETE |
| Record UNII |
UT3S5ZS2ZF
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| Record Status |
FAILED
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| Record Version |
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156614128
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122431-03-2
Created by
admin on Wed Apr 02 11:58:34 GMT 2025 , Edited by admin on Wed Apr 02 11:58:34 GMT 2025
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UT3S5ZS2ZF
Created by
admin on Wed Apr 02 11:58:34 GMT 2025 , Edited by admin on Wed Apr 02 11:58:34 GMT 2025
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PRIMARY |
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |
Agent Modifications
| Modification Process | Modification Role | Modification Type | Amount | Fragment Name | Fragment ID |
|---|---|---|---|---|---|
| SALT FORMATION | CHEMICAL |
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Hydrochloric Acid | QTT17582CB |
Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| MOIETY |
Amount:
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Chloride ion | Q32ZN48698 |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
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| Molecular Formula | CHEMICAL |
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