Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C25H29FN4O4S |
| Molecular Weight | 500.586 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C(F)C=C1[C@H](C)NC(=O)CC2=CC=C(C=C2)S(=O)(=O)NC3=NC=C(CC(C)C)C=N3
InChI
InChIKey=CKOLETHYECDWSS-KRWDZBQOSA-N
InChI=1S/C25H29FN4O4S/c1-16(2)11-19-14-27-25(28-15-19)30-35(32,33)21-8-5-18(6-9-21)12-24(31)29-17(3)22-13-20(26)7-10-23(22)34-4/h5-10,13-17H,11-12H2,1-4H3,(H,29,31)(H,27,28,30)/t17-/m0/s1
| Molecular Formula | C25H29FN4O4S |
| Molecular Weight | 500.586 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Gliflumide is a compound with a long-lasting hypoglycemic effect. This blood glucose lowering sulfonamide has shown a large decrease of blood glucose levels in healthy volunteers who where administered the drug orally or intravenously. A very similar reaction but delayed and prolonged response was observed for this drug compared to other insulin secretion-stimulating compounds (such as glibenclamide). High affinity of gliflumide to plasma proteins has been suggested to contribute to this delayed activity.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 17:26:05 GMT 2023
by
admin
on
Sat Dec 16 17:26:05 GMT 2023
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| Record UNII |
USE67B01YN
|
| Record Status |
Validated (UNII)
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| Record Version |
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NCI_THESAURUS |
C29711
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admin on Sat Dec 16 17:26:05 GMT 2023 , Edited by admin on Sat Dec 16 17:26:05 GMT 2023
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USE67B01YN
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C72947
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10436054
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C010968
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3721
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100000084202
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35273-88-2
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CHEMBL2104743
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SUB07924MIG
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DTXSID801043366
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admin on Sat Dec 16 17:26:05 GMT 2023 , Edited by admin on Sat Dec 16 17:26:05 GMT 2023
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
