CYMARIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C30H44O9
Molecular Weight	548.665
Optical Activity	UNSPECIFIED
Defined Stereocenters	12 / 12
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CO[C@H]1C[C@H](O[C@H]2CC[C@]3(C=O)[C@H]4CC[C@]5(C)[C@H](CC[C@]5(O)[C@@H]4CC[C@]3(O)C2)C6=CC(=O)OC6)O[C@H](C)[C@H]1O

InChI

InChIKey=XQCGNURMLWFQJR-ZNDDOCHDSA-N

InChI=1S/C30H44O9/c1-17-26(33)23(36-3)13-25(38-17)39-19-4-9-28(16-31)21-5-8-27(2)20(18-12-24(32)37-15-18)7-11-30(27,35)22(21)6-10-29(28,34)14-19/h12,16-17,19-23,25-26,33-35H,4-11,13-15H2,1-3H3/t17-,19+,20-,21+,22-,23+,25+,26-,27-,28+,29+,30+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C30H44O9
Molecular Weight	548.665
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	12 / 12
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3821940

Cymarin (or cymarine or k-strophanthidin-alpha) is a cardiac glycoside and an anti-arrhythmia and cardiotonic agent. Cymarin works as an inhibitor of Na+ /K+-ATPase . This inhibition has an inotropic effect on the cardiac muscles increasing their force by approximately 100%.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Sodium/potassium-transporting ATPase 34 Target ID: CHEMBL2095186 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6146536	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Cardiotonic effect of Apocynum venetum L. extracts on isolated guinea pig atrium.	2009-04	19002560

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:22:16 GMT 2025` Edited by `admin` on `Mon Mar 31 19:22:16 GMT 2025`
Record UNII	UK3LS8435E
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CYMARIN

Common Name

English

NSC-7522

Preferred Name

English

CYMARIN [MI]

Common Name

English

Cymarin [WHO-DD]

Common Name

English

CYMARINE

Common Name

English

K-STROPHANTHIN-ALPHA

Common Name

English

K-STROPHANTHIN-.ALPHA.

Common Name

English

3.BETA.-((2,6-DIDEOXY-3-O-METHYL-.BETA.-D-RIBO-HEXOPYRANOSYL)OXY)-5,14-DIHYDROXY-19-OXO-5.BETA.,14.BETA.-CARD-20(22)-ENOLIDE

Common Name

English

CYMARIN [MART.]

Common Name

English

Classification Tree Code System Code

WHO-ATC

C01AC03