BARMASTINE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C27H29N7O2
Molecular Weight	483.5649
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(CCN2CCC(CC2)NC3=NC4=C(N=CC=C4)N3CC5=CC=CO5)C(=O)N6C=CC=CC6=N1

InChI

InChIKey=LNSHWIZFFHXFPQ-UHFFFAOYSA-N

InChI=1S/C27H29N7O2/c1-19-22(26(35)33-13-3-2-8-24(33)29-19)11-16-32-14-9-20(10-15-32)30-27-31-23-7-4-12-28-25(23)34(27)18-21-6-5-17-36-21/h2-8,12-13,17,20H,9-11,14-16,18H2,1H3,(H,30,31)

HIDE SMILES / InChI

Molecular Formula	C27H29N7O2
Molecular Weight	483.5649
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800000106

Barmastine [bermastine, R 57959, ramastine], is an oral antihistamine agent which was being developed by Johnson & Johnson for use in asthma. Development was discontinued later.

Originator

Approval Year

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:33:25 GMT 2023` Edited by `admin` on `Fri Dec 15 15:33:25 GMT 2023`
Record UNII	UIF43N1HSV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BARMASTINE

Official Name

English

R 57959

Code

English

3-[2-[4-[(3-Furfuryl-3H-imidazo[4,5-b]pyridin-2-yl)amino]piperidino]ethyl]-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Systematic Name

English

BARMASTINE [USAN]

Common Name

English

R-57959

Code

English

barmastine [INN]

Common Name

English

4H-PYRIDO(1,2-A)PYRIMIDIN-4-ONE, 3-(2-(4-((3-(2-FURANYLMETHYL)-3H-IMIDAZO(4,5-B)PYRIDIN-2-YL)AMINO)-1-PIPERIDINYL)ETHYL)-2-METHYL-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578