TRANSFORMING GROWTH FACTOR .ALPHA. (HUMAN)

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NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Mon Mar 31 22:22:15 GMT 2025` Edited by `admin` on `Mon Mar 31 22:22:15 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	UH1S6NFW5D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRANSFORMING GROWTH FACTOR .ALPHA. (HUMAN)

Common Name

English

RH-POLYPEPTIDE-19

Preferred Name

English

TRANSFORMING GROWTH FACTOR .ALPHA. (RAT), 7-L-ASPARTIC ACID-15-L-PHENYLALANINE-28-L-ASPARTIC ACID-41-L-ALANINE-

Common Name

English

TRANSFORMING GROWTH FACTOR .ALPHA.

Common Name

English

VAL-VAL-SER-HIS-PHE-ASN-ASP-CYS-PRO-ASP-SER-HIS-THR-GLN-PHE-CYS-PHE-HIS-GLY-THR-CYS-ARG-PHE-LEU-VAL-GLN-GLU-ASP-LYS-PRO-ALA-CYS-VAL-CYS-HIS-SER-GLY-TYR-VAL-GLY-ALA-ARG-CYS-GLU-HIS-ALA-ASP-LEU-LEU-ALA

Common Name

English

EGF-LIKE TGF

Common Name

English

HUMAN TRANSFORMING GROWTH FACTOR .ALPHA.

Common Name

English

TGF-.ALPHA.

Common Name

English

TGF TYPE 1

Common Name

English

ETGF

Common Name

English

NEXPURE BIO TGFA

Brand Name

English

Code System Code Type Description

EPA CompTox

DTXSID00239474

Created by admin on Mon Mar 31 22:22:15 GMT 2025 , Edited by admin on Mon Mar 31 22:22:15 GMT 2025

PRIMARY

CAS

93585-89-8

Created by admin on Mon Mar 31 22:22:15 GMT 2025 , Edited by admin on Mon Mar 31 22:22:15 GMT 2025

ALTERNATIVE

SMS_ID

300000047868

Created by admin on Mon Mar 31 22:22:15 GMT 2025 , Edited by admin on Mon Mar 31 22:22:15 GMT 2025

PRIMARY

CAS

105186-99-0

Created by admin on Mon Mar 31 22:22:15 GMT 2025 , Edited by admin on Mon Mar 31 22:22:15 GMT 2025

PRIMARY

PUBCHEM

121494106

Created by admin on Mon Mar 31 22:22:15 GMT 2025 , Edited by admin on Mon Mar 31 22:22:15 GMT 2025

PRIMARY

FDA UNII

UH1S6NFW5D

Created by admin on Mon Mar 31 22:22:15 GMT 2025 , Edited by admin on Mon Mar 31 22:22:15 GMT 2025

PRIMARY

From	To
1_8	1_21
1_16	1_32
1_34	1_43

Related Record Type Details


					BA5V83N5BZ

ALLOGENEIC HUMAN AMNION/CHORION MEMBRANE

PARENT -> CONSTITUENT ALWAYS PRESENT

Amount:


					FP2PL0HRK8

INHIBITOR -> TARGET

Comments:

Binds to key residues in the C?terminal regions of TGF?? and epiregulin, preventing their binding to the EGFR. Engagement of the 2 targets by LY results in internalization of the transmembrane precursors and neutralization of the activity of the mature ligands in vitro.

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL