CEPADACURSEN

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 00:17:46 GMT 2025` Edited by `admin` on `Wed Apr 02 00:17:46 GMT 2025`
Nucleic Acid Type	OLIGONUCLEOTIDE
Sequence Type	COMPLETE
Record UNII	UGH88FK62E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CEPADACURSEN

Common Name

English

CIVI 007 FREE ACID

Preferred Name

English

CIVI-007 FREE ACID

Code

English

DNA, D(P-THIO)((2'-O,4'-C-METHYLENE)RA-(2'-O,4'-C-METHYLENE)RA-(2'-O,4'-C-METHYLENE)M5RU-G-C-T-A-C-A-A-A-A-(2'-O,4'-C-METHYLENE)RC-(2'-O,4'-C-METHYLENE)M5RC-(2'-O,4'-C-METHYLENE)M5RC-(2'-O,4'-C-METHYLENE)RA), 5'-(O-(6-((N2,N6-BIS(2-(2-(2-(2-((2-(ACETYLAM

Common Name

English

ALL-P-AMBO-5'-O-(26-((2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)-11,14-BIS((4-(2-(2-(2-((2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)ETHOXY)ETHOXY)ETHOXY)ACETAMIDO)BUTYL)-1,10,13,16-TETRAOXO-1-SULFANYL-2,18,21,24,26-PENTAOXA-9,12,15-TRIAZA-

Common Name

English

Code System Code Type Description

FDA UNII

UGH88FK62E

Created by admin on Wed Apr 02 00:17:46 GMT 2025 , Edited by admin on Wed Apr 02 00:17:46 GMT 2025

PRIMARY

SMS_ID

300000044624

Created by admin on Wed Apr 02 00:17:46 GMT 2025 , Edited by admin on Wed Apr 02 00:17:46 GMT 2025

PRIMARY

INN

11668

Created by admin on Wed Apr 02 00:17:46 GMT 2025 , Edited by admin on Wed Apr 02 00:17:46 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_4-1_13	10 / 16
2,'4'-locked-Ribose (alpha-L-LNA)	1_1-1_3;1_14-1_16	6 / 16

Linkage	Site Range	Site Count
Phosporothioate	1_2-1_16	15 / 15

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION	[1_14] [1_15]	SITE_SPECIFIC			5-METHYL-2'-O,4'-C-METHYLENECYTIDINE	HH0X5P4HEO