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Details

Stereochemistry ACHIRAL
Molecular Formula 2CO3.Ca.Mg
Molecular Weight 184.401
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CALCIUM MAGNESIUM CARBONATE

SMILES

[Mg++].[Ca++].[O-]C([O-])=O.[O-]C([O-])=O

InChI

InChIKey=HHSPVTKDOHQBKF-UHFFFAOYSA-J
InChI=1S/2CH2O3.Ca.Mg/c2*2-1(3)4;;/h2*(H2,2,3,4);;/q;;2*+2/p-4

HIDE SMILES / InChI
Molecular Formula Ca
Molecular Weight 40.078
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Mg
Molecular Weight 24.305
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula CO3
Molecular Weight 60.0089
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/8342726 | https://www.ncbi.nlm.nih.gov/pubmed/3415787 | https://www.ncbi.nlm.nih.gov/pubmed/23115717

Calcium magnesium carbonate (dolomite), a mineral with the chemical formula CaMg(CO3)2, is made up of 60% calcium carbonate (equivalent to 24% calcium) and 40% magnesium carbonate (equivalent to 12% magnesium). It is recommended by lay periodicals as a desirable source of calcium and magnesium, but found to be also a source of potentially toxic heavy metals. Exposure to high atmospheric concentrations of this compound is likely to be associated with respiratory symptoms.

Originator

De Dolomieu, D.G.
1
Curator's Comment: Deodat Gratet de Dolomieu, a French geologist, was the first to describe dolomite in 1791.

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Alert to users of calcium supplements as antihypertensive agents due to trace metal contaminants.
1988 Jul
Antitumoral effect of bleomycin+dolomite combination treatment, in mice bearing Ehrlich ascites carcinoma.
1993 Sep-Oct
Dolomite supplementation improves bone metabolism through modulation of calcium-regulating hormone secretion in ovariectomized rats.
2005
Antiviral activities of heated dolomite powder.
2008 Dec
Effects of calcium magnesium carbonate and roughage level on feedlot performance, ruminal metabolism, and site and extent of digestion in steers fed high-grain diets.
2008 Nov
Effect of dolomite oral exposure in Wistar rats during organogenesis period of pregnancy.
2008 Sep
Effect of dolomite on the repair of bone defects in rats: histological study.
2010 Dec
Nanotoxicity of dolomite mineral of commercial importance in India.
2011 Feb
Evaluation of cytotoxic, oxidative stress, proinflammatory and genotoxic responses of micro- and nano-particles of dolomite on human lung epithelial cells A(549).
2012 Sep
Comparative cytotoxicity of dolomite nanoparticles in human larynx HEp2 and liver HepG2 cells.
2015 Jun
Patents

Patents

US2257544
1

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Dolomite powder contained particles of different shapes and size both microparticles (MPs) and nanoparticles (NPs), suggesting potential occupational exposure of these particles. An attempt was therefore, made to investigate dolomite toxicity in a particle size-dependent manner in human lung epithelial cells A(549). cytotoxicity profiles were estimated by exposing cells at concentration doses 100–1000 ug/ml by two different methods. LC50 values of MPs were 655 ug/ml and 675 ug/ml whereas for NPs were 278 ug/ml and 300 ug/ml in MTT and Trypan blue assays, respectively.
Substance Class Chemical
Created
by admin
on Fri Dec 15 21:31:14 GMT 2023
Edited
by admin
on Fri Dec 15 21:31:14 GMT 2023
Record UNII
UG9H2002BF
Record Status Validated (UNII)
Record Version
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Name Type Language
CALCIUM MAGNESIUM CARBONATE
WHO-DD  
Systematic Name English
VIRPAZAR
Common Name English
MYANIT A 20
Common Name English
CALCIUM MAGNESIUM DICARBONATE
Systematic Name English
MICRODOL X
Common Name English
SAXOCARB 1000
Common Name English
STRADOLOMIT A 20
Common Name English
SINDOFORM K
Common Name English
Dolomite [WHO-DD]
Common Name English
SNOWHITE 20
Common Name English
PIGMENT WHITE 18:1
Common Name English
CALCIDOL
Common Name English
DOLOMITE
INCI   WHO-DD  
INCI  
Official Name English
CALMAG
Common Name English
Calcium magnesium carbonate [WHO-DD]
Common Name English
UWANURIYO
Common Name English
CALFIX
Common Name English
DOLOMITE [INCI]
Common Name English
Classification Tree Code System Code
DSLD 1574 (Number of products:2)
Created by admin on Fri Dec 15 21:31:14 GMT 2023 , Edited by admin on Fri Dec 15 21:31:14 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID70892191
Created by admin on Fri Dec 15 21:31:14 GMT 2023 , Edited by admin on Fri Dec 15 21:31:14 GMT 2023
PRIMARY
CAS
7000-29-5
Created by admin on Fri Dec 15 21:31:14 GMT 2023 , Edited by admin on Fri Dec 15 21:31:14 GMT 2023
PRIMARY
PUBCHEM
61833
Created by admin on Fri Dec 15 21:31:14 GMT 2023 , Edited by admin on Fri Dec 15 21:31:14 GMT 2023
PRIMARY
ECHA (EC/EINECS)
230-274-9
Created by admin on Fri Dec 15 21:31:14 GMT 2023 , Edited by admin on Fri Dec 15 21:31:14 GMT 2023
PRIMARY
EVMPD
SUB33635
Created by admin on Fri Dec 15 21:31:14 GMT 2023 , Edited by admin on Fri Dec 15 21:31:14 GMT 2023
PRIMARY
GRAS Notification (GRN No.)
696
Created by admin on Fri Dec 15 21:31:14 GMT 2023 , Edited by admin on Fri Dec 15 21:31:14 GMT 2023
PRIMARY
FDA UNII
UG9H2002BF
Created by admin on Fri Dec 15 21:31:14 GMT 2023 , Edited by admin on Fri Dec 15 21:31:14 GMT 2023
PRIMARY
MESH
C028042
Created by admin on Fri Dec 15 21:31:14 GMT 2023 , Edited by admin on Fri Dec 15 21:31:14 GMT 2023
PRIMARY
GRAS Notification (GRN No.)
806
Created by admin on Fri Dec 15 21:31:14 GMT 2023 , Edited by admin on Fri Dec 15 21:31:14 GMT 2023
PRIMARY
SMS_ID
100000127590
Created by admin on Fri Dec 15 21:31:14 GMT 2023 , Edited by admin on Fri Dec 15 21:31:14 GMT 2023
PRIMARY
ECHA (EC/EINECS)
240-440-2
Created by admin on Fri Dec 15 21:31:14 GMT 2023 , Edited by admin on Fri Dec 15 21:31:14 GMT 2023
ALTERNATIVE
RXCUI
23622
Created by admin on Fri Dec 15 21:31:14 GMT 2023 , Edited by admin on Fri Dec 15 21:31:14 GMT 2023
PRIMARY RxNorm
CAS
16389-88-1
Created by admin on Fri Dec 15 21:31:14 GMT 2023 , Edited by admin on Fri Dec 15 21:31:14 GMT 2023
ALTERNATIVE
NIH
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