1,3-DICHLOROACETONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C3H4Cl2O
Molecular Weight	126.969
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClCC(=O)CCl

InChI

InChIKey=SUNMBRGCANLOEG-UHFFFAOYSA-N

InChI=1S/C3H4Cl2O/c4-1-3(6)2-5/h1-2H2

HIDE SMILES / InChI

Molecular Formula	C3H4Cl2O
Molecular Weight	126.969
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Elevated levels of activated and inactivated thrombin-activatable fibrinolysis inhibitor in patients with sepsis.	2010-12	21253429
Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics.	2010-11-24	21124831
Bovipain-2, the falcipain-2 ortholog, is expressed in intraerythrocytic stages of the tick-transmitted hemoparasite Babesia bovis.	2010-11-23	21092313
Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs).	2010-11	20615447
A general scheme for synthesis of substrate-based polyketide labels for acyl carrier proteins.	2010-10-01	20801036
A critical tryptophan and Ca2+ in activation and catalysis of TPPI, the enzyme deficient in classic late-infantile neuronal ceroid lipofuscinosis.	2010-08-03	20689811
Alkylating HIV-1 Nef - a potential way of HIV intervention.	2010-07-26	20659345
Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen.	2010-07-23	20479008
Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells.	2010-07-15	20630104
Inositol hexakisphosphate-induced autoprocessing of large bacterial protein toxins.	2010-07-08	20628577
Effects of acute insulin-induced hypoglycemia on indices of inflammation: putative mechanism for aggravating vascular disease in diabetes.	2010-07	20587725
Role of vimA in cell surface biogenesis in Porphyromonas gingivalis.	2010-07	20378652
Eptifibatide: The evidence for its role in the management of acute coronary syndromes.	2010-06-15	20694065
Characterization of hemin-binding protein 35 (HBP35) in Porphyromonas gingivalis: its cellular distribution, thioredoxin activity and role in heme utilization.	2010-05-25	20500879
The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase.	2010-05-18	20689744
Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear.	2010-04-29	20454680
Annexin-II, DNA, and histones serve as factor H ligands on the surface of apoptotic cells.	2010-02-05	19951950
Expression of a novel chimeric truncated t-PA in CHO cells based on in silico experiments.	2010	20885932
Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis?	2010	20553633
IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India.	2009-12-14	20011600
Quantitative assessment of DNA replication to monitor microgametogenesis in Plasmodium berghei.	2009-12	19712704
An evaluation of the chick cardiomyocyte micromass system for identification of teratogens in a blind trial.	2009-12	19646523
N-tosyl-L-phenylalanine chloromethyl ketone inhibits NF-kappaB activation by blocking specific cysteine residues of IkappaB kinase beta and p65/RelA.	2009-08-04	19591457
Mechanical and kinetic effects of shortened tropomyosin reconstituted into myofibrils.	2009-08	19255776
Catalytic activity and inhibition of wegener antigen proteinase 3 on the cell surface of human polymorphonuclear neutrophils.	2009-07-24	19447886
Mechanisms of growth inhibition in human papillomavirus positive and negative cervical cancer cells by the chloromethyl ketone protease inhibitor, succinyl-alanine-alanine-proline-phenylalanine chloromethyl ketone.	2009-07	19401497
The Stimulation of CD147 Induces MMP-9 Expression through ERK and NF-kappaB in Macrophages: Implication for Atherosclerosis.	2009-06	20107538
The role of Bcl-xL and nuclear factor-kappaB in the effect of taxol on the viability of dendritic cells.	2009-06	19461204
HIV-1 Tat co-operates with IFN-gamma and TNF-alpha to increase CXCL10 in human astrocytes.	2009-05-28	19479051
Purification and characterization of a serine protease (CESP) from mature coconut endosperm.	2009-05-09	19426537
Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.	2009-05-08	19254953
Selectivity profiling of DegP substrates and inhibitors.	2009-04-01	19233659
Protoporphyrin IX enhancement by 5-aminolaevulinic acid peptide derivatives and the effect of RNA silencing on intracellular metabolism.	2009-03-10	19240715
Insect chymotrypsins: chloromethyl ketone inactivation and substrate specificity relative to possible coevolutional adaptation of insects and plants.	2009-03	19194984
Metabolic acidosis increases intracellular calcium in bone cells through activation of the proton receptor OGR1.	2009-02	18847331
Synthesis and biological evaluation of a chitobiose-based peptide N-glycanase inhibitor library.	2009-01-16	19072094
Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets.	2009-01-09	19010784
Distinct roles of Plasmodium rhomboid 1 in parasite development and malaria pathogenesis.	2009-01	19148267
Digestive proteolytic activity in the Sunn pest, Eurygaster integriceps.	2009	20053125
NtCP56, a new cysteine protease in Nicotiana tabacum L., involved in pollen grain development.	2009	19246592
Treatment with N-tosyl-l-phenylalanine chloromethyl ketone after the onset of collagen-induced arthritis reduces joint erosion and NF-kappaB activation.	2008-10-24	18706406
A novel bioluminescent protease assay using engineered firefly luciferase.	2008-10-17	20161840
Neutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase-inhibitor complex.	2008-08-12	18699987
Bone-derived SDF-1 stimulates IL-6 release via CXCR4, ERK and NF-kappaB pathways and promotes osteoclastogenesis in human oral cancer cells.	2008-08	18310089
Anti-chaperone betaA3/A1(102-117) peptide interacting sites in human alphaB-crystallin.	2008-03-26	18401461
A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice.	2008-01-29	18232732
Intramolecular cross-linking evaluated as a structural probe of the protein folding transition state.	2007-12-04	17985931
Protective effects of recombinant kunitz-domain 1 of human tissue factor pathway inhibitor-2 against 2-chloroethyl ethyl sulfide toxicity in vitro.	2007-12-03	18213399
Protective effects of recombinant kunitz-domain 1 of human tissue factor pathway inhibitor-2 against 2-chloroethyl ethyl sulfide toxicity in vitro.	2007-07-10	17846661
Mesangial cells of lupus-prone mice are sensitive to chemokine production.	2007	17617918

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:02:17 GMT 2025` Edited by `admin` on `Mon Mar 31 18:02:17 GMT 2025`
Record UNII	UFH8559WS5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1,3-DICHLOROACETONE

Systematic Name

English

BISCHLOROMETHYL KETONE

Preferred Name

English

BISCHLOROMETHYL KETONE [HSDB]

Common Name

English

NSC-8745

Code

English

1,3-DICHLOROPROPANONE

Systematic Name

English

1,3-DICHLOROACETONE [MI]

Common Name

English

1,3-DICHLORO-2-PROPANONE

Systematic Name

English

Code System Code Type Description

WIKIPEDIA

Bis(chloromethyl) ketone