1,3-DICHLOROACETONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C3H4Cl2O
Molecular Weight	126.969
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClCC(=O)CCl

InChI

InChIKey=SUNMBRGCANLOEG-UHFFFAOYSA-N

InChI=1S/C3H4Cl2O/c4-1-3(6)2-5/h1-2H2

HIDE SMILES / InChI

Molecular Formula	C3H4Cl2O
Molecular Weight	126.969
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Investigation of the behaviour of haloketones in water samples.	2001 Aug	11513422
Effect of serine protease inhibitors on posttraumatic brain injury and neuronal apoptosis.	2001 Feb	11161625
Linear competitive inhibition of human tissue kallikrein by 4-aminobenzamidine and benzamidine and linear mixed inhibition by 4-nitroaniline and aniline.	2001 Jan	11151026
Modulation of hepatocyte thiol content by medium composition: implications for toxicity studies.	2002 Jun	12020599
Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.	2004 Dec 30	15615538
Do alkylating agents modify the histidine residue of the desensitized butyrylcholinesterase?	2004 Nov	15648971
Increased heat shock protein 70 expression following toxicant-mediated cytotoxicity: a ubiquitous marker of toxicant exposure?	2005 Apr	16180985
Natural and derivative brevetoxins: historical background, multiplicity, and effects.	2005 May	15866774
New insight into CCN3 interactions--nuclear CCN3 : fact or fantasy?	2006 Aug 8	16895594
A novel surface protein of Trichomonas vaginalis is regulated independently by low iron and contact with vaginal epithelial cells.	2006 Jan 31	16448556
A protease inhibitor specifically inhibits growth of HPV-infected keratinocytes.	2006 Jun	16564747
The oncolytic effect in vivo of reovirus on tumour cells that have survived reovirus cell killing in vitro.	2006 Oct 23	17047650
Photocatalytical degradation of 1,3-dichloro-2-propanol aqueous solutions by using an immobilized TiO2 photoreactor.	2006 Sep 21	16707212
Mesangial cells of lupus-prone mice are sensitive to chemokine production.	2007	17617918
Treatment with N-tosyl-l-phenylalanine chloromethyl ketone after the onset of collagen-induced arthritis reduces joint erosion and NF-kappaB activation.	2008 Oct 24	18706406
NtCP56, a new cysteine protease in Nicotiana tabacum L., involved in pollen grain development.	2009	19246592
Selectivity profiling of DegP substrates and inhibitors.	2009 Apr 1	19233659
Mechanical and kinetic effects of shortened tropomyosin reconstituted into myofibrils.	2009 Aug	19255776
N-tosyl-L-phenylalanine chloromethyl ketone inhibits NF-kappaB activation by blocking specific cysteine residues of IkappaB kinase beta and p65/RelA.	2009 Aug 4	19591457
An evaluation of the chick cardiomyocyte micromass system for identification of teratogens in a blind trial.	2009 Dec	19646523
Synthesis and biological evaluation of a chitobiose-based peptide N-glycanase inhibitor library.	2009 Jan 16	19072094
Mechanisms of growth inhibition in human papillomavirus positive and negative cervical cancer cells by the chloromethyl ketone protease inhibitor, succinyl-alanine-alanine-proline-phenylalanine chloromethyl ketone.	2009 Jul	19401497
Catalytic activity and inhibition of wegener antigen proteinase 3 on the cell surface of human polymorphonuclear neutrophils.	2009 Jul 24	19447886
Insect chymotrypsins: chloromethyl ketone inactivation and substrate specificity relative to possible coevolutional adaptation of insects and plants.	2009 Mar	19194984
Protoporphyrin IX enhancement by 5-aminolaevulinic acid peptide derivatives and the effect of RNA silencing on intracellular metabolism.	2009 Mar 10	19240715
Purification and characterization of a serine protease (CESP) from mature coconut endosperm.	2009 May 9	19426537
Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis?	2010	20553633
Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear.	2010 Apr 29	20454680
Elevated levels of activated and inactivated thrombin-activatable fibrinolysis inhibitor in patients with sepsis.	2010 Dec	21253429
Effects of acute insulin-induced hypoglycemia on indices of inflammation: putative mechanism for aggravating vascular disease in diabetes.	2010 Jul	20587725
Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen.	2010 Jul 23	20479008
Inositol hexakisphosphate-induced autoprocessing of large bacterial protein toxins.	2010 Jul 8	20628577
Characterization of hemin-binding protein 35 (HBP35) in Porphyromonas gingivalis: its cellular distribution, thioredoxin activity and role in heme utilization.	2010 May 25	20500879
Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs).	2010 Nov	20615447
A general scheme for synthesis of substrate-based polyketide labels for acyl carrier proteins.	2010 Oct 1	20801036

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:35:39 GMT 2023` Edited by `admin` on `Fri Dec 15 15:35:39 GMT 2023`
Record UNII	UFH8559WS5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1,3-DICHLOROACETONE

Systematic Name

English

BISCHLOROMETHYL KETONE [HSDB]

Common Name

English

NSC-8745

Code

English

1,3-DICHLOROPROPANONE

Systematic Name

English

1,3-DICHLOROACETONE [MI]

Common Name

English

BISCHLOROMETHYL KETONE

Systematic Name

English

1,3-DICHLORO-2-PROPANONE

Systematic Name

English

Code System Code Type Description

WIKIPEDIA

Bis(chloromethyl) ketone