Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | Al.Cl.HO.H2O |
| Molecular Weight | 97.457 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 1 |
SHOW SMILES / InChI
SMILES
O.[OH-].[Al+3].[Cl-]
InChI
InChIKey=YCLAMANSVUJYPT-UHFFFAOYSA-L
InChI=1S/Al.ClH.2H2O/h;1H;2*1H2/q+3;;;/p-2
| Molecular Formula | HO |
| Molecular Weight | 17.0073 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | Al |
| Molecular Weight | 26.9815 |
| Charge | 3 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | Cl |
| Molecular Weight | 35.453 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including
https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html
Curator's Comment: Description was created based on several sources, including
https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html
Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate.
The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2364031 |
|||
Target ID: GO:0042310 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | DOMEBORO Approved UseTemporarily relieves minor skin irritations due to:
– Poison ivy | – Poison oak
– Poison sumac | – Insect bites
– Athlete’s foot | – Rashes caused by soaps, detergents, cosmetics, or jewelry |
|||
| Curative | DOMEBORO Approved UseThis medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection. |
PubMed
| Title | Date | PubMed |
|---|---|---|
| The ineffectiveness of aluminum subacetate in rheumatoid arthritis. | 1948 Apr 8 |
|
| Hypermagnesemia following aluminum phosphide poisoning. | 1991 Feb |
|
| Requirement for intramolecular domain interaction in activation of G protein alpha subunit by aluminum fluoride and GDP but not by GTP gamma S. | 1994 Nov 25 |
|
| Manipulation of B cell antigen receptor tyrosine phosphorylation using aluminum fluoride and sodium orthovanadate. | 1995 Nov |
|
| The antibacterial activity of acetic acid and Burow's solution as topical otological preparations. | 1998 Oct |
|
| Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study. | 1999 May |
|
| Fluoride plus aluminum: useful tools in laboratory investigations, but messengers of false information. | 2002 |
|
| Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate, sodium magnesium silicate, zirconium silicate, attapulgite, bentonite, Fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite, and zeolite. | 2003 |
|
| Aluminum inclusion macrophagic myofasciitis: a recently identified condition. | 2003 Nov |
|
| The role of metals in neurodegenerative processes: aluminum, manganese, and zinc. | 2003 Nov 15 |
|
| Parenteral nutrition-associated cholestasis in neonates: the role of aluminum. | 2003 Sep |
|
| Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain. | 2003 Sep 15 |
|
| [Pharmaceutical and pharmacological evaluation of Burow's solution (aluminum acetate solution), hospital preparation, and development of its rapid preparation method]. | 2004 Nov |
|
| Aluminum: new recognition of an old problem. | 2005 Dec |
|
| Some aspects of astroglial functions and aluminum implications for neurodegeneration. | 2006 Aug 30 |
|
| Aluminum and other metals in Alzheimer's disease: a review of potential therapy with chelating agents. | 2006 Nov |
|
| Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration. | 2006 Nov |
|
| Aluminum and Alzheimer's disease: a new look. | 2006 Nov |
|
| The role of aluminum and copper on neuroinflammation and Alzheimer's disease. | 2006 Nov |
|
| Ototoxic effect of Burow solution applied to the guinea pig middle ear. | 2007 Aug |
|
| Neurological adverse events of immunization: experience with an aluminum adjuvanted meningococcal B outer membrane vesicle vaccine. | 2007 Oct |
|
| Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation. | 2007 Oct |
|
| Reversible myocardial injury associated with aluminum phosphide poisoning. | 2007 Sep |
|
| Ablative laser resurfacing: high-energy pulsed carbon dioxide and erbium:yttrium-aluminum-garnet. | 2007 Sep-Oct |
|
| Aluminum phosphide fatalities at mild exertion in asymptomatic children: a clue to understand the variations of the autopsy findings. | 2009 Aug |
|
| Altered glucose homeostasis in response to aluminium phosphide induced cellular oxygen deficit in rat. | 2010 Jul |
|
| Blood levels of methemoglobin in patients with aluminum phosphide poisoning and its correlation with patient's outcome. | 2011 Mar |
|
| Effect of acute aluminum phosphide exposure on rats: a biochemical and histological correlation. | 2012 Nov 23 |
|
| Pesticide exposure and depression among male private pesticide applicators in the agricultural health study. | 2014 Sep |
|
| Molecular basis of carcinogenicity of tungsten alloy particles. | 2015 Mar 15 |
Sample Use Guides
DOMEBORO® SOOTHING SOAK
– dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water
– stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use
For use as a soak:
– soak affected area for 15 to 30 minutes as needed, or as directed by a doctor
– repeat 3 times a day or as directed by a doctor
– discard solution after each use.
For use as a compress or wet dressing:
– soak a clean, soft cloth in the solution.
– apply cloth loosely to affected area for 15 to 30 minutes
– repeat as needed or as directed by a doctor
– discard solution after each use
Route of Administration:
Topical
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:40:49 GMT 2023
by
admin
on
Fri Dec 15 16:40:49 GMT 2023
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| Record UNII |
UCN889409V
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| Record Status |
Validated (UNII)
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CFR |
21 CFR 350.10
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543375
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CHEMBL2109019
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UCN889409V
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UCN889409V
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1327-41-9
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173763-15-0
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11097-68-0
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DB11108
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23053647
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C45678
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CONCEPT | Industrial Aid | ||
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C142918
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