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Details

Stereochemistry RACEMIC
Molecular Formula C22H22N2O6
Molecular Weight 410.4199
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DARUSENTAN, (±)-

SMILES

COC1=CC(OC)=NC(OC(C(O)=O)C(OC)(C2=CC=CC=C2)C3=CC=CC=C3)=N1

InChI

InChIKey=FEJVSJIALLTFRP-UHFFFAOYSA-N
InChI=1S/C22H22N2O6/c1-27-17-14-18(28-2)24-21(23-17)30-19(20(25)26)22(29-3,15-10-6-4-7-11-15)16-12-8-5-9-13-16/h4-14,19H,1-3H3,(H,25,26)

HIDE SMILES / InChI
Molecular Formula C22H22N2O6
Molecular Weight 410.4199
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Darusentan is a mixture of two isomers R and S, the last enantiomer is responsible for the therapeutic properties.

Approval Year

Unknown
149124
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries.
2010-08

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 22:57:35 GMT 2025
Edited
by admin
on Mon Mar 31 22:57:35 GMT 2025
Record UNII
UAG0ANS9HZ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DARUSENTAN, (±)-
Common Name English
DARUSENTAN (±)-FORM [MI]
Preferred Name English
BENZENEPROPANOIC ACID, .ALPHA.-((4,6-DIMETHOXY-2-PYRIMIDINYL)OXY)-.BETA.-METHOXY-.BETA.-PHENYL-
Systematic Name English
DARUSENTAN, (RS)-
Common Name English
Code System Code Type Description
PUBCHEM
9953358
Created by admin on Mon Mar 31 22:57:35 GMT 2025 , Edited by admin on Mon Mar 31 22:57:35 GMT 2025
PRIMARY
CAS
178306-46-2
Created by admin on Mon Mar 31 22:57:35 GMT 2025 , Edited by admin on Mon Mar 31 22:57:35 GMT 2025
PRIMARY
MERCK INDEX
m4100
Created by admin on Mon Mar 31 22:57:35 GMT 2025 , Edited by admin on Mon Mar 31 22:57:35 GMT 2025
PRIMARY Merck Index
FDA UNII
UAG0ANS9HZ
Created by admin on Mon Mar 31 22:57:35 GMT 2025 , Edited by admin on Mon Mar 31 22:57:35 GMT 2025
PRIMARY
NIH
NCATS
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