THIOURIDINE

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=S)NC2=O

InChIKey=ZLOIGESWDJYCTF-XVFCMESISA-N

InChI=1S/C9H12N2O5S/c12-3-4-6(13)7(14)8(16-4)11-2-1-5(17)10-9(11)15/h1-2,4,6-8,12-14H,3H2,(H,10,15,17)/t4-,6-,7-,8-/m1/s1

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Targets

Primary Target	Pharmacology	Condition	Potency
rRNA processing 1 Target ID: GO:0006364 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24025460	Inhibitor 8297
RNA 19 Target ID: CHEMBL2311222 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7531281 \| https://www.ncbi.nlm.nih.gov/pubmed/20946768	Crosslinking Agent 81

PubMed

Title	Date	PubMed
The temporal landscape of recursive splicing during Pol II transcription elongation in human cells.	2018 Aug	30148885
Expanding the Nucleoside Recoding Toolkit: Revealing RNA Population Dynamics with 6-Thioguanosine.	2018 Nov 7	30353734
Gaining insight into transcriptome-wide RNA population dynamics through the chemistry of 4-thiouridine.	2019 Jan	30370679
The RNA degradosome promotes tRNA quality control through clearance of hypomodified tRNA.	2019 Jan 22	30622183
Biomolecules of 2-Thiouracil, 4-Thiouracil and 2,4-Dithiouracil: A DFT Study of the Hydration, Molecular Docking and Effect in DNA:RNAMicrohelixes.	2019 Jul 15	31311161
Proteomic and transcriptomic experiments reveal an essential role of RNA degradosome complexes in shaping the transcriptome of Mycobacterium tuberculosis.	2019 Jun 20	30957850
Adventitious Virus Detection in Cells by High-Throughput Sequencing of Newly Synthesized RNAs: Unambiguous Differentiation of Cell Infection from Carryover of Viral Nucleic Acids.	2019 Jun 5	31167947
Effect of the sulfur atom on S2 and S4 positions of the uracil ring in different DNA:RNA hybrid microhelixes with three nucleotide base pairs.	2019 Mar	30676643
Thermodynamic and structural contributions of the 6-thioguanosine residue to helical properties of RNA.	2019 Mar 13	30867505
Quantification of experimentally induced nucleotide conversions in high-throughput sequencing datasets.	2019 May 20	31109287

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:17:35 GMT 2023` Edited by `admin` on `Fri Dec 15 18:17:35 GMT 2023`
Record UNII	U9TYQ2R33J
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

THIOURIDINE

Systematic Name

English

NSC-518132

Code

English

4-THIOURIDINE

Systematic Name

English

URIDINE, 4-THIO-

Systematic Name

English

Code System Code Type Description

PUBCHEM

3032615